HCSGD entry for TCF7

1. General information

Official gene symbolTCF7
Entrez ID6932
Gene full nametranscription factor 7 (T-cell specific, HMG-box)
Other gene symbolsTCF-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0021915Neural tube developmentIEAbiological_process
GO:0030538Embryonic genitalia morphogenesisIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIBAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0044336Canonical Wnt signaling pathway involved in negative regulation of apoptotic processIEAbiological_process
GO:0046632Alpha-beta T cell differentiationIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048619Embryonic hindgut morphogenesisIEAbiological_process
GO:0048699Generation of neuronsIBAbiological_process
GO:0060070Canonical Wnt signaling pathwayIBAbiological_process
GO:0071353Cellular response to interleukin-4IDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30705674940.42512840700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2680748522
GSE13712_SHEARUp0.0679692717
GSE13712_STATICUp0.2224712990
GSE19018Down-0.4013981946
GSE19899_A1Down-0.1088056055
GSE19899_A2Up0.2432623606
PubMed_21979375_A1Down-0.2831653621
PubMed_21979375_A2Up0.3147364584
GSE35957Down-0.2388340340
GSE36640Down-0.2910809000
GSE54402Up0.4408787141
GSE9593Down-0.0982481339
GSE43922Up0.2354659779
GSE24585Up0.1555780523
GSE37065Up0.1891874800
GSE28863_A1Down-0.0469109967
GSE28863_A2Up0.0227425418
GSE28863_A3Up0.2195454270
GSE28863_A4Down-0.0745572228
GSE48662Down-1.0433892054

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024837MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026207MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.