HCSGD entry for TCF7

1. General information

Official gene symbolTCF7
Entrez ID6932
Gene full nametranscription factor 7 (T-cell specific, HMG-box)
Other gene symbolsTCF-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIBA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIBAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0021915Neural tube developmentIEAbiological_process
GO:0030538Embryonic genitalia morphogenesisIEAbiological_process
GO:0033153T cell receptor V(D)J recombinationIEAbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIBAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0044336Canonical Wnt signaling pathway involved in negative regulation of apoptotic processIEAbiological_process
GO:0046632Alpha-beta T cell differentiationIEAbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048619Embryonic hindgut morphogenesisIEAbiological_process
GO:0048699Generation of neuronsIBAbiological_process
GO:0060070Canonical Wnt signaling pathwayIBAbiological_process
GO:0071353Cellular response to interleukin-4IDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30705674940.42512840700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2680748522
GSE13712_SHEARUp0.0679692717
GSE13712_STATICUp0.2224712990
GSE19018Down-0.4013981946
GSE19899_A1Down-0.1088056055
GSE19899_A2Up0.2432623606
PubMed_21979375_A1Down-0.2831653621
PubMed_21979375_A2Up0.3147364584
GSE35957Down-0.2388340340
GSE36640Down-0.2910809000
GSE54402Up0.4408787141
GSE9593Down-0.0982481339
GSE43922Up0.2354659779
GSE24585Up0.1555780523
GSE37065Up0.1891874800
GSE28863_A1Down-0.0469109967
GSE28863_A2Up0.0227425418
GSE28863_A3Up0.2195454270
GSE28863_A4Down-0.0745572228
GSE48662Down-1.0433892054

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024837MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026207MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.