HCSGD entry for STAT6

1. General information

Official gene symbolSTAT6
Entrez ID6778
Gene full namesignal transducer and activator of transcription 6, interleukin-4 induced
Other gene symbolsD12S1644 IL-4-STAT STAT6B STAT6C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0002296T-helper 1 cell lineage commitmentIEAbiological_process
GO:0002829Negative regulation of type 2 immune responseIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0033598Mammary gland epithelial cell proliferationIEAbiological_process
GO:0035771Interleukin-4-mediated signaling pathwayIEA IMPbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048295Positive regulation of isotype switching to IgE isotypesIEAbiological_process
GO:0060443Mammary gland morphogenesisIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:1902170Cellular response to reactive nitrogen speciesIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11030234410.56786378560.68764697291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2126817359
GSE13712_SHEARDown-0.2270067802
GSE13712_STATICUp0.0598923672
GSE19018Up0.0398942528
GSE19899_A1Down-0.1959538733
GSE19899_A2Up0.4428963609
PubMed_21979375_A1Up0.5497134844
PubMed_21979375_A2Up0.3896213302
GSE35957Up0.0072322998
GSE36640Up0.4717321792
GSE54402Down-0.0196371662
GSE9593Up0.3395436903
GSE43922Down-0.2670879512
GSE24585Up0.6372461241
GSE37065Up0.2057021170
GSE28863_A1Up0.0934032990
GSE28863_A2Up0.1333579626
GSE28863_A3Down-0.7870127300
GSE28863_A4Down-0.0065355580
GSE48662Down-0.1168347660

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017016MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT028991MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24925089For instance, JMJD3 can induce macrophage M2 polarization via STAT6 signaling
Entries Per Page
Displaying Page of