HCSGD entry for STAT6

1. General information

Official gene symbolSTAT6
Entrez ID6778
Gene full namesignal transducer and activator of transcription 6, interleukin-4 induced
Other gene symbolsD12S1644 IL-4-STAT STAT6B STAT6C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0002296T-helper 1 cell lineage commitmentIEAbiological_process
GO:0002829Negative regulation of type 2 immune responseIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0033598Mammary gland epithelial cell proliferationIEAbiological_process
GO:0035771Interleukin-4-mediated signaling pathwayIEA IMPbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048295Positive regulation of isotype switching to IgE isotypesIEAbiological_process
GO:0060443Mammary gland morphogenesisIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:1902170Cellular response to reactive nitrogen speciesIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11030234410.56786378560.68764697291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2126817359
GSE13712_SHEARDown-0.2270067802
GSE13712_STATICUp0.0598923672
GSE19018Up0.0398942528
GSE19899_A1Down-0.1959538733
GSE19899_A2Up0.4428963609
PubMed_21979375_A1Up0.5497134844
PubMed_21979375_A2Up0.3896213302
GSE35957Up0.0072322998
GSE36640Up0.4717321792
GSE54402Down-0.0196371662
GSE9593Up0.3395436903
GSE43922Down-0.2670879512
GSE24585Up0.6372461241
GSE37065Up0.2057021170
GSE28863_A1Up0.0934032990
GSE28863_A2Up0.1333579626
GSE28863_A3Down-0.7870127300
GSE28863_A4Down-0.0065355580
GSE48662Down-0.1168347660

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017016MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT028991MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24925089For instance, JMJD3 can induce macrophage M2 polarization via STAT6 signaling
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