HCSGD entry for SREBF2

1. General information

Official gene symbolSREBF2
Entrez ID6721
Gene full namesterol regulatory element binding transcription factor 2
Other gene symbolsSREBP2 bHLHd2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0000247C-8 sterol isomerase activityIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0012507ER to Golgi transport vesicle membraneIEAcellular_component
GO:0032937SREBP-SCAP-Insig complexIDAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0055098Response to low-density lipoprotein particleIEPbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071499Cellular response to laminar fluid shear stressNASbiological_process
GO:0072368Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0090370Negative regulation of cholesterol effluxIDAbiological_process
GO:2000188Regulation of cholesterol homeostasisIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22232742300.74698718130.90345053251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1353981225
GSE13712_SHEARDown-0.3053712415
GSE13712_STATICDown-0.5577932072
GSE19018Up0.0571276100
GSE19899_A1Up0.0388298875
GSE19899_A2Up0.7664490272
PubMed_21979375_A1Down-0.1574868742
PubMed_21979375_A2Up0.4728395605
GSE35957Up0.2848459254
GSE36640Up0.0778829844
GSE54402Up0.0372616517
GSE9593Up0.2273404127
GSE43922Up0.1088812163
GSE24585Down-0.0251976041
GSE37065Up0.0489607197
GSE28863_A1Up0.1365394960
GSE28863_A2Up0.3123239399
GSE28863_A3Down-0.2760996324
GSE28863_A4Down-0.2777229579
GSE48662Up0.2354099224

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018283MicroarrayFunctional MTI (Weak)18185580
hsa-miR-877-5pMIMAT0004949MIRT037293CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043540CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049508CLASHFunctional MTI (Weak)23622248
hsa-miR-28-5pMIMAT0000085MIRT050003CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.