HCSGD entry for SREBF2

1. General information

Official gene symbolSREBF2
Entrez ID6721
Gene full namesterol regulatory element binding transcription factor 2
Other gene symbolsSREBP2 bHLHd2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0000247C-8 sterol isomerase activityIDAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006629Lipid metabolic processTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0012507ER to Golgi transport vesicle membraneIEAcellular_component
GO:0032937SREBP-SCAP-Insig complexIDAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0055098Response to low-density lipoprotein particleIEPbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071499Cellular response to laminar fluid shear stressNASbiological_process
GO:0072368Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0090370Negative regulation of cholesterol effluxIDAbiological_process
GO:2000188Regulation of cholesterol homeostasisIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22232742300.74698718130.90345053251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1353981225
GSE13712_SHEARDown-0.3053712415
GSE13712_STATICDown-0.5577932072
GSE19018Up0.0571276100
GSE19899_A1Up0.0388298875
GSE19899_A2Up0.7664490272
PubMed_21979375_A1Down-0.1574868742
PubMed_21979375_A2Up0.4728395605
GSE35957Up0.2848459254
GSE36640Up0.0778829844
GSE54402Up0.0372616517
GSE9593Up0.2273404127
GSE43922Up0.1088812163
GSE24585Down-0.0251976041
GSE37065Up0.0489607197
GSE28863_A1Up0.1365394960
GSE28863_A2Up0.3123239399
GSE28863_A3Down-0.2760996324
GSE28863_A4Down-0.2777229579
GSE48662Up0.2354099224

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018283MicroarrayFunctional MTI (Weak)18185580
hsa-miR-877-5pMIMAT0004949MIRT037293CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043540CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049508CLASHFunctional MTI (Weak)23622248
hsa-miR-28-5pMIMAT0000085MIRT050003CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.