HCSGD entry for SPG7
1. General information
| Official gene symbol | SPG7 |
|---|---|
| Entrez ID | 6687 |
| Gene full name | spastic paraplegia 7 (pure and complicated autosomal recessive) |
| Other gene symbols | CAR CMAR PGN SPG5C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007005 | Mitochondrion organization | IEA | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008089 | Anterograde axon cargo transport | IEA | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008233 | Peptidase activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0051082 | Unfolded protein binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4236539911 | 0.9536911402 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0382694781 |
| GSE13712_SHEAR | Down | -0.1058871652 |
| GSE13712_STATIC | Up | 0.1823534466 |
| GSE19018 | Up | 0.1298566712 |
| GSE19899_A1 | Up | 0.1459112950 |
| GSE19899_A2 | Up | 0.0992753682 |
| PubMed_21979375_A1 | Up | 0.2086375260 |
| PubMed_21979375_A2 | Up | 0.0802640026 |
| GSE35957 | Up | 0.1614182970 |
| GSE36640 | Down | -0.0135064361 |
| GSE54402 | Up | 0.0180849743 |
| GSE9593 | Down | -0.1761105122 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.2429763767 |
| GSE28863_A2 | Up | 0.1194277217 |
| GSE28863_A3 | Down | -0.0225539237 |
| GSE28863_A4 | Up | 0.0278139150 |
| GSE48662 | Up | 0.0821710415 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
