HCSGD entry for SPG7

1. General information

Official gene symbolSPG7
Entrez ID6687
Gene full namespastic paraplegia 7 (pure and complicated autosomal recessive)
Other gene symbolsCAR CMAR PGN SPG5C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004222Metalloendopeptidase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005739MitochondrionTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008089Anterograde axon cargo transportIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008233Peptidase activityTASmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0051082Unfolded protein bindingTASmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42365399110.95369114020.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0382694781
GSE13712_SHEARDown-0.1058871652
GSE13712_STATICUp0.1823534466
GSE19018Up0.1298566712
GSE19899_A1Up0.1459112950
GSE19899_A2Up0.0992753682
PubMed_21979375_A1Up0.2086375260
PubMed_21979375_A2Up0.0802640026
GSE35957Up0.1614182970
GSE36640Down-0.0135064361
GSE54402Up0.0180849743
GSE9593Down-0.1761105122
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.2429763767
GSE28863_A2Up0.1194277217
GSE28863_A3Down-0.0225539237
GSE28863_A4Up0.0278139150
GSE48662Up0.0821710415

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.