HCSGD entry for SLIT3
1. General information
| Official gene symbol | SLIT3 |
|---|---|
| Entrez ID | 6586 |
| Gene full name | slit homolog 3 (Drosophila) |
| Other gene symbols | MEGF5 SLIL2 SLIT1 Slit-3 slit2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005509 | Calcium ion binding | IEA NAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005739 | Mitochondrion | NAS | cellular_component |
| GO:0007411 | Axon guidance | IDA TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0021834 | Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | IDA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEP | biological_process |
| GO:0035385 | Roundabout signaling pathway | IMP | biological_process |
| GO:0048495 | Roundabout binding | IPI | molecular_function |
| GO:0048846 | Axon extension involved in axon guidance | IDA | biological_process |
| GO:0050919 | Negative chemotaxis | IDA | biological_process |
| GO:0051414 | Response to cortisol | IEP | biological_process |
| GO:0061364 | Apoptotic process involved in luteolysis | IEP | biological_process |
| GO:0070100 | Negative regulation of chemokine-mediated signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1190313856 | 0.5367398009 | 0.7070870684 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3423084484 |
| GSE13712_SHEAR | Up | 0.0342905820 |
| GSE13712_STATIC | Down | -0.0421170165 |
| GSE19018 | Up | 0.0743342756 |
| GSE19899_A1 | Up | 0.0946100156 |
| GSE19899_A2 | Up | 0.0989923694 |
| PubMed_21979375_A1 | Up | 0.0048007743 |
| PubMed_21979375_A2 | Down | -0.0578847513 |
| GSE35957 | Up | 0.2493493958 |
| GSE36640 | Down | -0.0428734265 |
| GSE54402 | Up | 0.0305002540 |
| GSE9593 | Down | -0.3513299053 |
| GSE43922 | Up | 0.0224304874 |
| GSE24585 | Up | 0.0019270648 |
| GSE37065 | Down | -0.5431652453 |
| GSE28863_A1 | Up | 1.1812706082 |
| GSE28863_A2 | Up | 0.8235078222 |
| GSE28863_A3 | Up | 0.3642719044 |
| GSE28863_A4 | Down | -0.1486385386 |
| GSE48662 | Up | 0.6490518592 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26047956 | Our results showed that the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes, there was gradual increase in cell viability along with restoration of the expression of Topo IIbeta and potential repair proteins |
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