HCSGD entry for SLIT3

1. General information

Official gene symbolSLIT3
Entrez ID6586
Gene full nameslit homolog 3 (Drosophila)
Other gene symbolsMEGF5 SLIL2 SLIT1 Slit-3 slit2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005509Calcium ion bindingIEA NASmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005739MitochondrionNAScellular_component
GO:0007411Axon guidanceIDA TASbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0021834Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationIDAbiological_process
GO:0030308Negative regulation of cell growthIMPbiological_process
GO:0032870Cellular response to hormone stimulusIEPbiological_process
GO:0035385Roundabout signaling pathwayIMPbiological_process
GO:0048495Roundabout bindingIPImolecular_function
GO:0048846Axon extension involved in axon guidanceIDAbiological_process
GO:0050919Negative chemotaxisIDAbiological_process
GO:0051414Response to cortisolIEPbiological_process
GO:0061364Apoptotic process involved in luteolysisIEPbiological_process
GO:0070100Negative regulation of chemokine-mediated signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11903138560.53673980090.70708706841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3423084484
GSE13712_SHEARUp0.0342905820
GSE13712_STATICDown-0.0421170165
GSE19018Up0.0743342756
GSE19899_A1Up0.0946100156
GSE19899_A2Up0.0989923694
PubMed_21979375_A1Up0.0048007743
PubMed_21979375_A2Down-0.0578847513
GSE35957Up0.2493493958
GSE36640Down-0.0428734265
GSE54402Up0.0305002540
GSE9593Down-0.3513299053
GSE43922Up0.0224304874
GSE24585Up0.0019270648
GSE37065Down-0.5431652453
GSE28863_A1Up1.1812706082
GSE28863_A2Up0.8235078222
GSE28863_A3Up0.3642719044
GSE28863_A4Down-0.1486385386
GSE48662Up0.6490518592

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26047956Our results showed that the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes, there was gradual increase in cell viability along with restoration of the expression of Topo IIbeta and potential repair proteins
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