HCSGD entry for SLC25A1
1. General information
| Official gene symbol | SLC25A1 |
|---|---|
| Entrez ID | 6576 |
| Gene full name | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 |
| Other gene symbols | CTP D2L2AD SEA SLC20A3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005743 | Mitochondrial inner membrane | IEA TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | TAS | biological_process |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0006820 | Anion transport | TAS | biological_process |
| GO:0015137 | Citrate transmembrane transporter activity | TAS | molecular_function |
| GO:0015711 | Organic anion transport | TAS | biological_process |
| GO:0015746 | Citrate transport | TAS | biological_process |
| GO:0015849 | Organic acid transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019432 | Triglyceride biosynthetic process | TAS | biological_process |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0035338 | Long-chain fatty-acyl-CoA biosynthetic process | TAS | biological_process |
| GO:0035674 | Tricarboxylic acid transmembrane transport | TAS | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046942 | Carboxylic acid transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4827392880 | 0.1036352646 | 0.9999902473 | 0.6171376300 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0932219914 |
| GSE13712_SHEAR | Down | -0.4678894294 |
| GSE13712_STATIC | Down | -0.3113413673 |
| GSE19018 | Down | -0.1064718960 |
| GSE19899_A1 | Down | -1.0504883405 |
| GSE19899_A2 | Up | 0.4587517077 |
| PubMed_21979375_A1 | Up | 0.3365656174 |
| PubMed_21979375_A2 | Up | 0.9828159343 |
| GSE35957 | Down | -0.2709498320 |
| GSE36640 | Up | 0.0399693778 |
| GSE54402 | Down | -0.0946720396 |
| GSE9593 | Up | 0.2300975298 |
| GSE43922 | Down | -0.2568678046 |
| GSE24585 | Down | -0.2206451604 |
| GSE37065 | Down | -0.1384695793 |
| GSE28863_A1 | Down | -0.1753404617 |
| GSE28863_A2 | Down | -0.1512303723 |
| GSE28863_A3 | Down | -0.0221756553 |
| GSE28863_A4 | Up | 0.0899011593 |
| GSE48662 | Up | 0.5601795039 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001333 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT001333 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001593 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018228 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037274 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037655 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038480 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039928 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042855 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045980 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051777 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26998679 | A microporous covalent triazine polymer (CTP) network with a high surface area was synthesized via the Friedel-Crafts reaction and employed as a potential transport system for drug delivery and controlled release |
| 26998679 | The CTP was transformed to the nanoscale region by intense ultrasonication followed by filtration to yield nanoscale CTP (NCTP) |
| 21932444 | A proteomic analysis was performed in domestic cats (Felis catus) to compare cloned term placentas (CTP) obtained from cesarean section (CS) to control placentas obtained from CS or vaginal delivery |
| 21932444 | The expression of 20 proteins was altered in CTP (p<0 |
| 21932444 | A total of 13 proteins were up-regulated in CTP, including apoptosis-related cathepsin D (CD), annexin A1 and heat shock protein 27 (HSP 27), and seven proteins were down-regulated in CTP, including prohibitin (PHB) |
| 21464199 | We have demonstrated that depletion of CTP induced by cyclopentenyl cytosine (CPEC; NSC 375575), a specific inhibitor of the enzyme CTP synthetase, induces irreversible growth arrest and senescence characterized by altered morphology and expression of senescence-associated beta-galactosidase activity in MCF-7 breast cancer cells expressing wild-type p53 |
| 21464199 | Both senescence of MCF-7 cells and differentiation of MDA-MB-231 cells were prevented by repletion of CTP through the cytidine salvage pathway |
| 21464199 | Mechanistic studies revealed that CTP depletion induced a rapid translocation of nucleolar proteins, including nucleostemin and nucleolin into the nucleoplasm |
| 21464199 | We conclude that CTP depletion and the resulting nucleolar stress response results in a senescence-like growth arrest through activation of p53, whereas cells with mutated p53 undergo differentiation or apoptotic cell death |
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