HCSGD entry for SLC25A1

1. General information

Official gene symbolSLC25A1
Entrez ID6576
Gene full namesolute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
Other gene symbolsCTP D2L2AD SEA SLC20A3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005743Mitochondrial inner membraneIEA TAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006094GluconeogenesisTASbiological_process
GO:0006810TransportIEAbiological_process
GO:0006820Anion transportTASbiological_process
GO:0015137Citrate transmembrane transporter activityTASmolecular_function
GO:0015711Organic anion transportTASbiological_process
GO:0015746Citrate transportTASbiological_process
GO:0015849Organic acid transportTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019432Triglyceride biosynthetic processTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035338Long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0035674Tricarboxylic acid transmembrane transportTASbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046942Carboxylic acid transportTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48273928800.10363526460.99999024730.6171376300

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0932219914
GSE13712_SHEARDown-0.4678894294
GSE13712_STATICDown-0.3113413673
GSE19018Down-0.1064718960
GSE19899_A1Down-1.0504883405
GSE19899_A2Up0.4587517077
PubMed_21979375_A1Up0.3365656174
PubMed_21979375_A2Up0.9828159343
GSE35957Down-0.2709498320
GSE36640Up0.0399693778
GSE54402Down-0.0946720396
GSE9593Up0.2300975298
GSE43922Down-0.2568678046
GSE24585Down-0.2206451604
GSE37065Down-0.1384695793
GSE28863_A1Down-0.1753404617
GSE28863_A2Down-0.1512303723
GSE28863_A3Down-0.0221756553
GSE28863_A4Up0.0899011593
GSE48662Up0.5601795039

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001333pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1MIMAT0000416MIRT001333Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-let-7b-5pMIMAT0000063MIRT001593ProteomicsFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT018228MicroarrayFunctional MTI (Weak)18185580
hsa-miR-877-5pMIMAT0004949MIRT037274CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037655CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038480CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039928CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042855CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045980CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051777CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26998679A microporous covalent triazine polymer (CTP) network with a high surface area was synthesized via the Friedel-Crafts reaction and employed as a potential transport system for drug delivery and controlled release
26998679The CTP was transformed to the nanoscale region by intense ultrasonication followed by filtration to yield nanoscale CTP (NCTP)
21932444A proteomic analysis was performed in domestic cats (Felis catus) to compare cloned term placentas (CTP) obtained from cesarean section (CS) to control placentas obtained from CS or vaginal delivery
21932444The expression of 20 proteins was altered in CTP (p<0
21932444A total of 13 proteins were up-regulated in CTP, including apoptosis-related cathepsin D (CD), annexin A1 and heat shock protein 27 (HSP 27), and seven proteins were down-regulated in CTP, including prohibitin (PHB)
21464199We have demonstrated that depletion of CTP induced by cyclopentenyl cytosine (CPEC; NSC 375575), a specific inhibitor of the enzyme CTP synthetase, induces irreversible growth arrest and senescence characterized by altered morphology and expression of senescence-associated beta-galactosidase activity in MCF-7 breast cancer cells expressing wild-type p53
21464199Both senescence of MCF-7 cells and differentiation of MDA-MB-231 cells were prevented by repletion of CTP through the cytidine salvage pathway
21464199Mechanistic studies revealed that CTP depletion induced a rapid translocation of nucleolar proteins, including nucleostemin and nucleolin into the nucleoplasm
21464199We conclude that CTP depletion and the resulting nucleolar stress response results in a senescence-like growth arrest through activation of p53, whereas cells with mutated p53 undergo differentiation or apoptotic cell death
Entries Per Page
Displaying Page of