HCSGD entry for SLC12A2

1. General information

Official gene symbolSLC12A2
Entrez ID6558
Gene full namesolute carrier family 12 (sodium/potassium/chloride transporters), member 2
Other gene symbolsBSC BSC2 NKCC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006813Potassium ion transportIEAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0006972Hyperosmotic responseIEAbiological_process
GO:0007214Gamma-aminobutyric acid signaling pathwayIEAbiological_process
GO:0008511Sodium:potassium:chloride symporter activityIEAmolecular_function
GO:0015377Cation:chloride symporter activityIEAmolecular_function
GO:0015696Ammonium transportIDAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030321Transepithelial chloride transportIDAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0045795Positive regulation of cell volumeIEAbiological_process
GO:0050910Detection of mechanical stimulus involved in sensory perception of soundIEAbiological_process
GO:0051739Ammonia transmembrane transporter activityIDAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0070634Transepithelial ammonium transportIDAbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01170269370.84550347630.27205836271.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2404822091
GSE13712_SHEARDown-0.0292577425
GSE13712_STATICDown-0.0455196710
GSE19018Down-0.6512715441
GSE19899_A1Up1.1749197856
GSE19899_A2Up0.4821967354
PubMed_21979375_A1Up0.4062995122
PubMed_21979375_A2Up1.2067077510
GSE35957Up0.0373136899
GSE36640Up0.5075278854
GSE54402Up0.8657245196
GSE9593Up0.0736516991
GSE43922Up0.1315146697
GSE24585Down-0.0300969558
GSE37065Down-0.0012757303
GSE28863_A1Up0.0820965780
GSE28863_A2Up0.5892902433
GSE28863_A3Down-0.4747567349
GSE28863_A4Down-0.0938466297
GSE48662Down-0.1544739726

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Potassium ChlorideDB00761 APRD01322
BumetanideDB00887 APRD00294
QuinethazoneDB01325 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001417pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028509ProteomicsFunctional MTI (Weak)18668040
hsa-let-7c-5pMIMAT0000064MIRT051865CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.