HCSGD entry for SLC12A2

1. General information

Official gene symbolSLC12A2
Entrez ID6558
Gene full namesolute carrier family 12 (sodium/potassium/chloride transporters), member 2
Other gene symbolsBSC BSC2 NKCC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006813Potassium ion transportIEAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0006972Hyperosmotic responseIEAbiological_process
GO:0007214Gamma-aminobutyric acid signaling pathwayIEAbiological_process
GO:0008511Sodium:potassium:chloride symporter activityIEAmolecular_function
GO:0015377Cation:chloride symporter activityIEAmolecular_function
GO:0015696Ammonium transportIDAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030321Transepithelial chloride transportIDAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0045795Positive regulation of cell volumeIEAbiological_process
GO:0050910Detection of mechanical stimulus involved in sensory perception of soundIEAbiological_process
GO:0051739Ammonia transmembrane transporter activityIDAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0070634Transepithelial ammonium transportIDAbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01170269370.84550347630.27205836271.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2404822091
GSE13712_SHEARDown-0.0292577425
GSE13712_STATICDown-0.0455196710
GSE19018Down-0.6512715441
GSE19899_A1Up1.1749197856
GSE19899_A2Up0.4821967354
PubMed_21979375_A1Up0.4062995122
PubMed_21979375_A2Up1.2067077510
GSE35957Up0.0373136899
GSE36640Up0.5075278854
GSE54402Up0.8657245196
GSE9593Up0.0736516991
GSE43922Up0.1315146697
GSE24585Down-0.0300969558
GSE37065Down-0.0012757303
GSE28863_A1Up0.0820965780
GSE28863_A2Up0.5892902433
GSE28863_A3Down-0.4747567349
GSE28863_A4Down-0.0938466297
GSE48662Down-0.1544739726

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Potassium ChlorideDB00761 APRD01322
BumetanideDB00887 APRD00294
QuinethazoneDB01325 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001417pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028509ProteomicsFunctional MTI (Weak)18668040
hsa-let-7c-5pMIMAT0000064MIRT051865CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.