HCSGD entry for BMP6

1. General information

Official gene symbolBMP6
Entrez ID654
Gene full namebone morphogenetic protein 6
Other gene symbolsVGR VGR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001654Eye developmentIEAbiological_process
GO:0001822Kidney developmentIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0003323Type B pancreatic cell developmentIDAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIMPbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0010039Response to iron ionIEAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0014823Response to activityIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0030539Male genitalia developmentIEAbiological_process
GO:0031988Membrane-bounded vesicleIEAcellular_component
GO:0032026Response to magnesium ionIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0032349Positive regulation of aldosterone biosynthetic processIDAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA NASbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0050714Positive regulation of protein secretionNASbiological_process
GO:0051216Cartilage developmentIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0070700BMP receptor bindingIPImolecular_function
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:2000105Positive regulation of DNA-dependent DNA replicationNASbiological_process
GO:2000860Positive regulation of aldosterone secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07199352990.27102903770.57153938480.9956392603

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1672164009
GSE13712_SHEARUp0.0067634393
GSE13712_STATICDown-0.1935661546
GSE19018Down-0.1799704874
GSE19899_A1Up0.0514761153
GSE19899_A2Up0.5132597270
PubMed_21979375_A1Up0.8294151997
PubMed_21979375_A2Down-0.0814025347
GSE35957Up0.5483813904
GSE36640Down-0.1382876802
GSE54402Up0.6978305971
GSE9593Up0.0135796053
GSE43922Up0.7886754863
GSE24585Down-0.6490181617
GSE37065Up1.1807329714
GSE28863_A1Up0.1531164657
GSE28863_A2Up0.1462875394
GSE28863_A3Up0.0262706903
GSE28863_A4Down-0.2470994781
GSE48662Down-0.5745365169

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022919MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20027224Interestingly, genes that showed the most significant link include those that mediate various signaling pathways implicated in colorectal tumorigenesis, such as BMP3 and BMP6 (BMP signaling), EPHA3, KIT, and FLT1 (receptor tyrosine kinases) and SMO (Hedgehog signaling)
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