HCSGD entry for BMP6
1. General information
Official gene symbol | BMP6 |
---|---|
Entrez ID | 654 |
Gene full name | bone morphogenetic protein 6 |
Other gene symbols | VGR VGR1 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001501 | Skeletal system development | TAS | biological_process |
GO:0001649 | Osteoblast differentiation | IEA | biological_process |
GO:0001654 | Eye development | IEA | biological_process |
GO:0001822 | Kidney development | IEA | biological_process |
GO:0001938 | Positive regulation of endothelial cell proliferation | IEA | biological_process |
GO:0001958 | Endochondral ossification | IEA | biological_process |
GO:0003323 | Type B pancreatic cell development | IDA | biological_process |
GO:0005125 | Cytokine activity | IEA | molecular_function |
GO:0005615 | Extracellular space | IEA | cellular_component |
GO:0005737 | Cytoplasm | IEA | cellular_component |
GO:0006954 | Inflammatory response | IEA | biological_process |
GO:0006955 | Immune response | IMP | biological_process |
GO:0008083 | Growth factor activity | IEA | molecular_function |
GO:0010039 | Response to iron ion | IEA | biological_process |
GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
GO:0014823 | Response to activity | IEA | biological_process |
GO:0030501 | Positive regulation of bone mineralization | IDA | biological_process |
GO:0030509 | BMP signaling pathway | IDA | biological_process |
GO:0030539 | Male genitalia development | IEA | biological_process |
GO:0031988 | Membrane-bounded vesicle | IEA | cellular_component |
GO:0032026 | Response to magnesium ion | IEA | biological_process |
GO:0032332 | Positive regulation of chondrocyte differentiation | IEA | biological_process |
GO:0032349 | Positive regulation of aldosterone biosynthetic process | IDA | biological_process |
GO:0032526 | Response to retinoic acid | IEA | biological_process |
GO:0040007 | Growth | IEA | biological_process |
GO:0045603 | Positive regulation of endothelial cell differentiation | IEA | biological_process |
GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
GO:0045669 | Positive regulation of osteoblast differentiation | IDA | biological_process |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA NAS | biological_process |
GO:0046982 | Protein heterodimerization activity | IDA | molecular_function |
GO:0050679 | Positive regulation of epithelial cell proliferation | IDA | biological_process |
GO:0050714 | Positive regulation of protein secretion | NAS | biological_process |
GO:0051216 | Cartilage development | IEA | biological_process |
GO:0051384 | Response to glucocorticoid | IEA | biological_process |
GO:0060395 | SMAD protein signal transduction | IDA | biological_process |
GO:0070700 | BMP receptor binding | IPI | molecular_function |
GO:0071260 | Cellular response to mechanical stimulus | IEA | biological_process |
GO:2000105 | Positive regulation of DNA-dependent DNA replication | NAS | biological_process |
GO:2000860 | Positive regulation of aldosterone secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0719935299 | 0.2710290377 | 0.5715393848 | 0.9956392603 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.1672164009 |
GSE13712_SHEAR | Up | 0.0067634393 |
GSE13712_STATIC | Down | -0.1935661546 |
GSE19018 | Down | -0.1799704874 |
GSE19899_A1 | Up | 0.0514761153 |
GSE19899_A2 | Up | 0.5132597270 |
PubMed_21979375_A1 | Up | 0.8294151997 |
PubMed_21979375_A2 | Down | -0.0814025347 |
GSE35957 | Up | 0.5483813904 |
GSE36640 | Down | -0.1382876802 |
GSE54402 | Up | 0.6978305971 |
GSE9593 | Up | 0.0135796053 |
GSE43922 | Up | 0.7886754863 |
GSE24585 | Down | -0.6490181617 |
GSE37065 | Up | 1.1807329714 |
GSE28863_A1 | Up | 0.1531164657 |
GSE28863_A2 | Up | 0.1462875394 |
GSE28863_A3 | Up | 0.0262706903 |
GSE28863_A4 | Down | -0.2470994781 |
GSE48662 | Down | -0.5745365169 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-124-3p | MIMAT0000422 | MIRT022919 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
20027224 | Interestingly, genes that showed the most significant link include those that mediate various signaling pathways implicated in colorectal tumorigenesis, such as BMP3 and BMP6 (BMP signaling), EPHA3, KIT, and FLT1 (receptor tyrosine kinases) and SMO (Hedgehog signaling) |
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