HCSGD entry for SLC6A12
1. General information
| Official gene symbol | SLC6A12 |
|---|---|
| Entrez ID | 6539 |
| Gene full name | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 |
| Other gene symbols | BGT-1 BGT1 GAT2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005328 | Neurotransmitter:sodium symporter activity | IEA | molecular_function |
| GO:0005332 | Gamma-aminobutyric acid:sodium symporter activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006811 | Ion transport | TAS | biological_process |
| GO:0006865 | Amino acid transport | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0009992 | Cellular water homeostasis | IEA | biological_process |
| GO:0010033 | Response to organic substance | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA TAS | cellular_component |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071474 | Cellular hyperosmotic response | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5188120170 | 0.9170628624 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0716614688 |
| GSE13712_SHEAR | Up | 0.0130299373 |
| GSE13712_STATIC | Down | -0.0513403802 |
| GSE19018 | Down | -0.0321750633 |
| GSE19899_A1 | Up | 0.1152856036 |
| GSE19899_A2 | Up | 0.1757455915 |
| PubMed_21979375_A1 | Down | -0.0422177189 |
| PubMed_21979375_A2 | Up | 0.1411721267 |
| GSE35957 | Up | 0.1458948381 |
| GSE36640 | Up | 0.0466142555 |
| GSE54402 | Up | 0.1609541376 |
| GSE9593 | Down | -0.1174531748 |
| GSE43922 | Up | 0.0277505958 |
| GSE24585 | Up | 0.1167815229 |
| GSE37065 | Up | 0.0978856465 |
| GSE28863_A1 | Down | -0.1462934741 |
| GSE28863_A2 | Down | -0.0919466721 |
| GSE28863_A3 | Up | 0.3314466373 |
| GSE28863_A4 | Up | 0.0591708625 |
| GSE48662 | Up | 0.1541629528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guvacine | DB08848 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017112 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043673 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
