HCSGD entry for SLC6A1

1. General information

Official gene symbolSLC6A1
Entrez ID6529
Gene full namesolute carrier family 6 (neurotransmitter transporter, GABA), member 1
Other gene symbolsGABATHG GABATR GAT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005328Neurotransmitter:sodium symporter activityIEAmolecular_function
GO:0005332Gamma-aminobutyric acid:sodium symporter activityIEAmolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006810TransportNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007612LearningIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009744Response to sucroseIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010288Response to lead ionIEAbiological_process
GO:0014054Positive regulation of gamma-aminobutyric acid secretionIEAbiological_process
GO:0014074Response to purine-containing compoundIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneTAScellular_component
GO:0030424AxonIEAcellular_component
GO:0032229Negative regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0051939Gamma-aminobutyric acid importIEAbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29097432470.74596500130.98984967051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2348632762
GSE13712_SHEARDown-0.0787968318
GSE13712_STATICDown-0.2579680216
GSE19018Up0.0361124425
GSE19899_A1Up0.2465095076
GSE19899_A2Up0.1200244580
PubMed_21979375_A1Down-0.2073750046
PubMed_21979375_A2Down-0.1392026449
GSE35957Up0.1696126225
GSE36640Up0.0357708045
GSE54402Down-0.0637551747
GSE9593Up0.0244041333
GSE43922Up0.1361983084
GSE24585Up0.1089818303
GSE37065Down-0.1394439754
GSE28863_A1Up0.1829281545
GSE28863_A2Up0.1235574280
GSE28863_A3Up0.3180300807
GSE28863_A4Up0.0977614366
GSE48662Down-0.5759237292

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TiagabineDB00906 APRD00344
GuvacineDB08848 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.