HCSGD entry for WNK4
1. General information
| Official gene symbol | WNK4 |
|---|---|
| Entrez ID | 65266 |
| Gene full name | WNK lysine deficient protein kinase 4 |
| Other gene symbols | PHA2B PRKWNK4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005923 | Tight junction | ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0006811 | Ion transport | ISS | biological_process |
| GO:0006821 | Chloride transport | IEA | biological_process |
| GO:0008104 | Protein localization | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | ISS | biological_process |
| GO:0050794 | Regulation of cellular process | ISS | biological_process |
| GO:0050801 | Ion homeostasis | IMP | biological_process |
| GO:0070294 | Renal sodium ion absorption | IMP | biological_process |
| GO:0072156 | Distal tubule morphogenesis | IMP | biological_process |
| GO:0090188 | Negative regulation of pancreatic juice secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9542685612 | 0.0039839710 | 0.9999902473 | 0.1281476829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2546046206 |
| GSE13712_SHEAR | Up | 0.6871038791 |
| GSE13712_STATIC | Up | 0.4357497609 |
| GSE19018 | Up | 0.2596093044 |
| GSE19899_A1 | Down | -0.0792222460 |
| GSE19899_A2 | Down | -0.5782998753 |
| PubMed_21979375_A1 | Down | -1.8128578191 |
| PubMed_21979375_A2 | Down | -0.6327763295 |
| GSE35957 | Up | 0.1811788909 |
| GSE36640 | Down | -1.2280791981 |
| GSE54402 | Down | -0.5268884093 |
| GSE9593 | Down | -0.1809870171 |
| GSE43922 | Down | -0.8215477908 |
| GSE24585 | Down | -0.1336705641 |
| GSE37065 | Down | -0.1645722149 |
| GSE28863_A1 | Down | -0.0503445803 |
| GSE28863_A2 | Down | -0.7829020352 |
| GSE28863_A3 | Down | -0.5443609147 |
| GSE28863_A4 | Down | -0.1255406856 |
| GSE48662 | Down | -0.0463581292 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-5p | MIMAT0000690 | MIRT004559 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20561597 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
