HCSGD entry for WNK4

1. General information

Official gene symbolWNK4
Entrez ID65266
Gene full nameWNK lysine deficient protein kinase 4
Other gene symbolsPHA2B PRKWNK4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEA ISSmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005923Tight junctionISScellular_component
GO:0006468Protein phosphorylationISSbiological_process
GO:0006811Ion transportISSbiological_process
GO:0006821Chloride transportIEAbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0050794Regulation of cellular processISSbiological_process
GO:0050801Ion homeostasisIMPbiological_process
GO:0070294Renal sodium ion absorptionIMPbiological_process
GO:0072156Distal tubule morphogenesisIMPbiological_process
GO:0090188Negative regulation of pancreatic juice secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95426856120.00398397100.99999024730.1281476829

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2546046206
GSE13712_SHEARUp0.6871038791
GSE13712_STATICUp0.4357497609
GSE19018Up0.2596093044
GSE19899_A1Down-0.0792222460
GSE19899_A2Down-0.5782998753
PubMed_21979375_A1Down-1.8128578191
PubMed_21979375_A2Down-0.6327763295
GSE35957Up0.1811788909
GSE36640Down-1.2280791981
GSE54402Down-0.5268884093
GSE9593Down-0.1809870171
GSE43922Down-0.8215477908
GSE24585Down-0.1336705641
GSE37065Down-0.1645722149
GSE28863_A1Down-0.0503445803
GSE28863_A2Down-0.7829020352
GSE28863_A3Down-0.5443609147
GSE28863_A4Down-0.1255406856
GSE48662Down-0.0463581292

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-296-5pMIMAT0000690MIRT004559Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20561597
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.