HCSGD entry for SKIV2L
1. General information
| Official gene symbol | SKIV2L |
|---|---|
| Entrez ID | 6499 |
| Gene full name | superkiller viralicidic activity 2-like (S. cerevisiae) |
| Other gene symbols | 170A DDX13 HLP SKI2 SKI2W SKIV2 THES2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0016818 | Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | IEA | molecular_function |
| GO:0055087 | Ski complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0491640325 | 0.9354311234 | 0.4877672446 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0646989425 |
| GSE13712_SHEAR | Up | 0.2898304478 |
| GSE13712_STATIC | Down | -0.0405026548 |
| GSE19018 | Up | 0.0931119731 |
| GSE19899_A1 | Up | 0.2301179444 |
| GSE19899_A2 | Up | 0.3963096889 |
| PubMed_21979375_A1 | Up | 0.1863512219 |
| PubMed_21979375_A2 | Up | 0.5925325860 |
| GSE35957 | Down | -0.4502761510 |
| GSE36640 | Up | 0.2789885349 |
| GSE54402 | Up | 0.2951378124 |
| GSE9593 | Down | -0.3151596234 |
| GSE43922 | Up | 0.3604149940 |
| GSE24585 | Up | 0.0770304857 |
| GSE37065 | Down | -0.0254805399 |
| GSE28863_A1 | Up | 0.5058483862 |
| GSE28863_A2 | Up | 0.7369063773 |
| GSE28863_A3 | Down | -0.1727362931 |
| GSE28863_A4 | Down | -0.2114981463 |
| GSE48662 | Up | 0.1417619542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT046701 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051423 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24505412 | In addition, SKI-II reduced cigarette smoke mediated oxidative stress, macrophages and neutrophil infiltration and markers of inflammation in mice |
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