HCSGD entry for SIX3

1. General information

Official gene symbolSIX3
Entrez ID6496
Gene full nameSIX homeobox 3
Other gene symbolsHPE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006606Protein import into nucleusIEAbiological_process
GO:0007420Brain developmentTASbiological_process
GO:0007601Visual perceptionTASbiological_process
GO:0021536Diencephalon developmentIEAbiological_process
GO:0021537Telencephalon developmentIEAbiological_process
GO:0021797Forebrain anterior/posterior pattern specificationIEAbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048512Circadian behaviorIEAbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31104469810.92997194260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0143301629
GSE13712_SHEARUp0.0279503348
GSE13712_STATICDown-0.0032389878
GSE19018Up0.1252918436
GSE19899_A1Up0.0566937073
GSE19899_A2Up0.0346698195
PubMed_21979375_A1Down-0.0210145501
PubMed_21979375_A2Up0.0231311465
GSE35957Up0.0226148921
GSE36640Up0.1297190068
GSE54402Up0.0123556437
GSE9593Up0.0215479805
GSE43922Up0.1745744062
GSE24585Down-0.1215616722
GSE37065Up0.0189397800
GSE28863_A1Down-0.0732341769
GSE28863_A2Up0.0490645147
GSE28863_A3Up0.2589556048
GSE28863_A4Up0.1366311476
GSE48662Up0.9916317716

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.