HCSGD entry for SIX3

1. General information

Official gene symbolSIX3
Entrez ID6496
Gene full nameSIX homeobox 3
Other gene symbolsHPE2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006606Protein import into nucleusIEAbiological_process
GO:0007420Brain developmentTASbiological_process
GO:0007601Visual perceptionTASbiological_process
GO:0021536Diencephalon developmentIEAbiological_process
GO:0021537Telencephalon developmentIEAbiological_process
GO:0021797Forebrain anterior/posterior pattern specificationIEAbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048512Circadian behaviorIEAbiological_process
GO:0060235Lens induction in camera-type eyeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31104469810.92997194260.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0143301629
GSE13712_SHEARUp0.0279503348
GSE13712_STATICDown-0.0032389878
GSE19018Up0.1252918436
GSE19899_A1Up0.0566937073
GSE19899_A2Up0.0346698195
PubMed_21979375_A1Down-0.0210145501
PubMed_21979375_A2Up0.0231311465
GSE35957Up0.0226148921
GSE36640Up0.1297190068
GSE54402Up0.0123556437
GSE9593Up0.0215479805
GSE43922Up0.1745744062
GSE24585Down-0.1215616722
GSE37065Up0.0189397800
GSE28863_A1Down-0.0732341769
GSE28863_A2Up0.0490645147
GSE28863_A3Up0.2589556048
GSE28863_A4Up0.1366311476
GSE48662Up0.9916317716

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.