HCSGD entry for SIAH1

1. General information

Official gene symbolSIAH1
Entrez ID6477
Gene full namesiah E3 ubiquitin protein ligase 1
Other gene symbolsSIAH1A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004842Ubiquitin-protein ligase activityIDA IMP ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005769Early endosomeIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDA IEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008022Protein C-terminus bindingIEA IPImolecular_function
GO:0008270Zinc ion bindingIDA IEA ISSmolecular_function
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0030163Protein catabolic processIDAbiological_process
GO:0030877Beta-catenin destruction complexIDAcellular_component
GO:0031648Protein destabilizationIEAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processISSbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processISSbiological_process
GO:0051402Neuron apoptotic processIEA ISSbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97894675350.04023156420.99999024730.3788201359

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0307386089
GSE13712_SHEARDown-0.0250492057
GSE13712_STATICDown-0.0304692229
GSE19018Up0.1764327725
GSE19899_A1Down-0.4828860741
GSE19899_A2Down-0.5186130079
PubMed_21979375_A1Down-0.5470227613
PubMed_21979375_A2Down-0.6635813204
GSE35957Down-0.1428845086
GSE36640Down-0.7121593066
GSE54402Down-0.1022230931
GSE9593Down-0.3721322585
GSE43922Down-0.3533622741
GSE24585Up0.0755341598
GSE37065Down-0.1266700633
GSE28863_A1Up0.1308235856
GSE28863_A2Up0.0164574984
GSE28863_A3Down-0.1535428371
GSE28863_A4Down-0.0045828595
GSE48662Down-0.3748180801

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-424-5pMIMAT0001341MIRT005887Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI21062812
hsa-miR-505-5pMIMAT0004776MIRT037958CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26437300However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC
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