HCSGD entry for SIAH1

1. General information

Official gene symbolSIAH1
Entrez ID6477
Gene full namesiah E3 ubiquitin protein ligase 1
Other gene symbolsSIAH1A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004842Ubiquitin-protein ligase activityIDA IMP ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005769Early endosomeIEAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006508ProteolysisTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDA IEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008022Protein C-terminus bindingIEA IPImolecular_function
GO:0008270Zinc ion bindingIDA IEA ISSmolecular_function
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0030163Protein catabolic processIDAbiological_process
GO:0030877Beta-catenin destruction complexIDAcellular_component
GO:0031648Protein destabilizationIEAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processISSbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processISSbiological_process
GO:0051402Neuron apoptotic processIEA ISSbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97894675350.04023156420.99999024730.3788201359

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0307386089
GSE13712_SHEARDown-0.0250492057
GSE13712_STATICDown-0.0304692229
GSE19018Up0.1764327725
GSE19899_A1Down-0.4828860741
GSE19899_A2Down-0.5186130079
PubMed_21979375_A1Down-0.5470227613
PubMed_21979375_A2Down-0.6635813204
GSE35957Down-0.1428845086
GSE36640Down-0.7121593066
GSE54402Down-0.1022230931
GSE9593Down-0.3721322585
GSE43922Down-0.3533622741
GSE24585Up0.0755341598
GSE37065Down-0.1266700633
GSE28863_A1Up0.1308235856
GSE28863_A2Up0.0164574984
GSE28863_A3Down-0.1535428371
GSE28863_A4Down-0.0045828595
GSE48662Down-0.3748180801

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-424-5pMIMAT0001341MIRT005887Immunohistochemistry//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI21062812
hsa-miR-505-5pMIMAT0004776MIRT037958CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26437300However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC
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