HCSGD entry for ARHGEF28

1. General information

Official gene symbolARHGEF28
Entrez ID64283
Gene full nameRho guanine nucleotide exchange factor (GEF) 28
Other gene symbolsRGNEF RIP2 p190RHOGEF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003723RNA bindingIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0021955Central nervous system neuron axonogenesisIEAbiological_process
GO:0030154Cell differentiationIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060052Neurofilament cytoskeleton organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01647987160.15556051820.31592622000.7621022520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2819292692
GSE13712_SHEARUp0.4396973617
GSE13712_STATICUp0.1085418296
GSE19018Up0.4031187632
GSE19899_A1Down-0.0846029230
GSE19899_A2Down-0.2785768390
PubMed_21979375_A1Down-0.7654222987
PubMed_21979375_A2Up0.1268229802
GSE35957Up0.5037772333
GSE36640Up1.5380635144
GSE54402Down-0.5702188761
GSE9593Up1.1014690652
GSE43922Down-0.2620649726
GSE24585Up1.6836520710
GSE37065Up0.0774194193
GSE28863_A1Down-1.0448658073
GSE28863_A2Up0.8488578145
GSE28863_A3Down-0.1500141616
GSE28863_A4Down-0.0008752376
GSE48662Up0.2457388589

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016811MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.