HCSGD entry for SFRP4

1. General information

Official gene symbolSFRP4
Entrez ID6424
Gene full namesecreted frizzled-related protein 4
Other gene symbolsFRP-4 FRPHE sFRP-4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001944Vasculature developmentIBAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0007409AxonogenesisIRDbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008406Gonad developmentIBAbiological_process
GO:0009725Response to hormoneNASbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0022601Menstrual cycle phaseNASbiological_process
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0032589Neuron projection membraneIKRcellular_component
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0045606Positive regulation of epidermal cell differentiationIDAbiological_process
GO:0046329Negative regulation of JNK cascadeIBAbiological_process
GO:0046697DecidualizationIBAbiological_process
GO:0055062Phosphate ion homeostasisIDAbiological_process
GO:0060056Mammary gland involutionIBAbiological_process
GO:0060429Epithelium developmentIBAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIGIbiological_process
GO:1902174Positive regulation of keratinocyte apoptotic processIDAbiological_process
GO:2000119Negative regulation of sodium-dependent phosphate transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06824987650.03024889250.56122157350.3285620875

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2005071878
GSE13712_SHEARDown-0.0451645068
GSE13712_STATICUp0.0366101013
GSE19018Up0.0203090352
GSE19899_A1Up0.1015468006
GSE19899_A2Up0.0225734662
PubMed_21979375_A1Up0.0043949765
PubMed_21979375_A2Up0.0213055246
GSE35957Up2.7561832677
GSE36640Down-0.0075970575
GSE54402Down-0.0120432799
GSE9593Down-0.2330519829
GSE43922Up0.0050151692
GSE24585Up0.4005060440
GSE37065Up0.6836127781
GSE28863_A1Down-1.3844835453
GSE28863_A2Up1.8494332607
GSE28863_A3Down-1.2305607553
GSE28863_A4Down-0.5766877273
GSE48662Up0.2876320792

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030345MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.