HCSGD entry for SFRP4

1. General information

Official gene symbolSFRP4
Entrez ID6424
Gene full namesecreted frizzled-related protein 4
Other gene symbolsFRP-4 FRPHE sFRP-4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001944Vasculature developmentIBAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0007409AxonogenesisIRDbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008406Gonad developmentIBAbiological_process
GO:0009725Response to hormoneNASbiological_process
GO:0009790Embryo developmentIBAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0017147Wnt-protein bindingIBAmolecular_function
GO:0022601Menstrual cycle phaseNASbiological_process
GO:0030165PDZ domain bindingIBAmolecular_function
GO:0032589Neuron projection membraneIKRcellular_component
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0045606Positive regulation of epidermal cell differentiationIDAbiological_process
GO:0046329Negative regulation of JNK cascadeIBAbiological_process
GO:0046697DecidualizationIBAbiological_process
GO:0055062Phosphate ion homeostasisIDAbiological_process
GO:0060056Mammary gland involutionIBAbiological_process
GO:0060429Epithelium developmentIBAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIDA IMPbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIGIbiological_process
GO:1902174Positive regulation of keratinocyte apoptotic processIDAbiological_process
GO:2000119Negative regulation of sodium-dependent phosphate transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06824987650.03024889250.56122157350.3285620875

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2005071878
GSE13712_SHEARDown-0.0451645068
GSE13712_STATICUp0.0366101013
GSE19018Up0.0203090352
GSE19899_A1Up0.1015468006
GSE19899_A2Up0.0225734662
PubMed_21979375_A1Up0.0043949765
PubMed_21979375_A2Up0.0213055246
GSE35957Up2.7561832677
GSE36640Down-0.0075970575
GSE54402Down-0.0120432799
GSE9593Down-0.2330519829
GSE43922Up0.0050151692
GSE24585Up0.4005060440
GSE37065Up0.6836127781
GSE28863_A1Down-1.3844835453
GSE28863_A2Up1.8494332607
GSE28863_A3Down-1.2305607553
GSE28863_A4Down-0.5766877273
GSE48662Up0.2876320792

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030345MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.