HCSGD entry for TNMD
1. General information
| Official gene symbol | TNMD |
|---|---|
| Entrez ID | 64102 |
| Gene full name | tenomodulin |
| Other gene symbols | BRICD4 CHM1L TEM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001886 | Endothelial cell morphogenesis | IEA | biological_process |
| GO:0001937 | Negative regulation of endothelial cell proliferation | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016525 | Negative regulation of angiogenesis | IEA | biological_process |
| GO:0035990 | Tendon cell differentiation | IEA | biological_process |
| GO:0071773 | Cellular response to BMP stimulus | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9077954409 | 0.3507662969 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1221760398 |
| GSE13712_SHEAR | Down | -0.1117315247 |
| GSE13712_STATIC | Up | 0.0176419446 |
| GSE19018 | Down | -0.1584870672 |
| GSE19899_A1 | Up | 0.0522995995 |
| GSE19899_A2 | Down | -0.1253074138 |
| PubMed_21979375_A1 | Down | -0.0916834348 |
| PubMed_21979375_A2 | Up | 0.1431764905 |
| GSE35957 | Up | 0.1229437206 |
| GSE36640 | Down | -0.0542661238 |
| GSE54402 | Up | 0.0166366623 |
| GSE9593 | Down | -0.1769468454 |
| GSE43922 | Up | 0.0157008178 |
| GSE24585 | Down | -0.1081632933 |
| GSE37065 | Down | -0.0981929798 |
| GSE28863_A1 | Down | -0.2774804118 |
| GSE28863_A2 | Down | -0.1069353847 |
| GSE28863_A3 | Up | 0.1546864288 |
| GSE28863_A4 | Up | 0.0801738508 |
| GSE48662 | Up | 0.0981810003 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27383874 | A Prospectus of Tenomodulin |
| 27383874 | The human tenomodulin encoding gene is mapped to capital HA, Cyrillic chromosome and encodes a polypeptide consisting of 317 alpha amino acids |
| 27383874 | Tenomodulin is predominantly expressed in dense connective hypovascularized tissues such as tendons, skeletal muscle epimysium, and ligaments |
| 27383874 | Furthermore, tenomodulin is an efficient marker of tenocyte differentiation and plays an important role in the regulation of tenocyte proliferation, tendon development, and angiogenesis inhibition |
| 27383874 | A number of tenomodulin gene polymorphisms have been recently associated with a risk of obesity, diabetes, systemic immune mediators, cholesterol levels, Alzheimer disease, and age-related macular degeneration |
| 27383874 | Tenomodulin is involved in cell adhesion, determination of cell morphology, cell aging and bone mineral density |
| 25351164 | Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells |
| 25351164 | Tenomodulin (Tnmd) is a well-known gene marker for the tendon and ligament lineage, but its exact functions in these tissues still remain elusive |
| 25351164 | In this study, we investigated Tnmd loss of function in mouse tendon stem/progenitor cells (mTSPC) by implicating a previously established Tnmd knockout (KO) mouse model |
| 25351164 | In contrast, self-renewal assays validated that Tnmd KO TSPC exhibit significantly reduced proliferative potential, which was also reflected in lower Cyclin D1 levels |
| 25351164 | When analyzing possible cellular mechanisms behind the observed decreased self-renewability of Tnmd KO TSPC, we found that cellular senescence plays a major role, starting earlier and cumulating more in Tnmd KO compared with control TSPC |
| 25351164 | Finally, the proliferative effect of Tnmd in TSPC was confirmed with transient transfection of Tnmd cDNA into Tnmd KO TSPC, which rescued their proliferative deficit |
| 25351164 | Taken together, we can report that loss of Tnmd affects significantly the self-renewal and senescence properties, but not the multipotential of TSPC |
| 23106341 | There was a higher protein expression of Sox9, but a lower mRNA expression of Col1a1, Scx, and Tnmd in TDSCs (CI) in a basal medium |
| 21627568 | The mRNA expression of tendon-related markers, scleraxis (Scx) and tenomodulin (Tnmd), was measured by quantitative real-time reverse transcription-polymerase chain reaction |
| 21627568 | The expression of Scx and Tnmd was lower in the late, compared with early and mid, passages of TDSCs |
Entries Per Page
Displaying Page of
