| 27383874 | A Prospectus of Tenomodulin |
| 27383874 | The human tenomodulin encoding gene is mapped to capital HA, Cyrillic chromosome and encodes a polypeptide consisting of 317 alpha amino acids |
| 27383874 | Tenomodulin is predominantly expressed in dense connective hypovascularized tissues such as tendons, skeletal muscle epimysium, and ligaments |
| 27383874 | Furthermore, tenomodulin is an efficient marker of tenocyte differentiation and plays an important role in the regulation of tenocyte proliferation, tendon development, and angiogenesis inhibition |
| 27383874 | A number of tenomodulin gene polymorphisms have been recently associated with a risk of obesity, diabetes, systemic immune mediators, cholesterol levels, Alzheimer disease, and age-related macular degeneration |
| 27383874 | Tenomodulin is involved in cell adhesion, determination of cell morphology, cell aging and bone mineral density |
| 25351164 | Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells |
| 25351164 | Tenomodulin (Tnmd) is a well-known gene marker for the tendon and ligament lineage, but its exact functions in these tissues still remain elusive |
| 25351164 | In this study, we investigated Tnmd loss of function in mouse tendon stem/progenitor cells (mTSPC) by implicating a previously established Tnmd knockout (KO) mouse model |
| 25351164 | In contrast, self-renewal assays validated that Tnmd KO TSPC exhibit significantly reduced proliferative potential, which was also reflected in lower Cyclin D1 levels |
| 25351164 | When analyzing possible cellular mechanisms behind the observed decreased self-renewability of Tnmd KO TSPC, we found that cellular senescence plays a major role, starting earlier and cumulating more in Tnmd KO compared with control TSPC |
| 25351164 | Finally, the proliferative effect of Tnmd in TSPC was confirmed with transient transfection of Tnmd cDNA into Tnmd KO TSPC, which rescued their proliferative deficit |
| 25351164 | Taken together, we can report that loss of Tnmd affects significantly the self-renewal and senescence properties, but not the multipotential of TSPC |
| 23106341 | There was a higher protein expression of Sox9, but a lower mRNA expression of Col1a1, Scx, and Tnmd in TDSCs (CI) in a basal medium |
| 21627568 | The mRNA expression of tendon-related markers, scleraxis (Scx) and tenomodulin (Tnmd), was measured by quantitative real-time reverse transcription-polymerase chain reaction |
| 21627568 | The expression of Scx and Tnmd was lower in the late, compared with early and mid, passages of TDSCs |
