HCSGD entry for SDC2

1. General information

Official gene symbolSDC2
Entrez ID6383
Gene full namesyndecan 2
Other gene symbolsCD362 HSPG HSPG1 SYND2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006024Glycosaminoglycan biosynthetic processTASbiological_process
GO:0006027Glycosaminoglycan catabolic processTASbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008092Cytoskeletal protein bindingIEAmolecular_function
GO:0008150Biological_processNDbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030203Glycosaminoglycan metabolic processTASbiological_process
GO:0030204Chondroitin sulfate metabolic processTASbiological_process
GO:0031000Response to caffeineIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043202Lysosomal lumenTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048813Dendrite morphogenesisIEAbiological_process
GO:0048814Regulation of dendrite morphogenesisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99597959420.00074347860.99999024730.0513624672

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9302155890
GSE13712_SHEARDown-0.4980684499
GSE13712_STATICDown-0.6076124622
GSE19018Down-0.3500574128
GSE19899_A1Down-1.7628538836
GSE19899_A2Down-2.1301397763
PubMed_21979375_A1Down-1.6490270579
PubMed_21979375_A2Down-1.7037021020
GSE35957Down-1.0644917704
GSE36640Up0.1899084954
GSE54402Down-1.7848414757
GSE9593Up0.0677756328
GSE43922Down-0.2097119968
GSE24585Down-0.2512858628
GSE37065Up0.1103173856
GSE28863_A1Up0.0208139427
GSE28863_A2Up0.0478506220
GSE28863_A3Down-0.2230186252
GSE28863_A4Down-0.1689020376
GSE48662Down-0.1511052080

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SargramostimDB00020 BTD00035 | BIOD00035

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19466596In this study, we analyzed APRIL and HSPG expression in the colon carcinoma cell line, SW480 by Western blot and RT-PCR
19466596And the up-regulation of APRIL and HSPG expression was found in SW480
19466596Furthermore, cellular senescence due to a decreased level of APRIL expression was associated with engagement of HSPG
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