HCSGD entry for CXCL5
1. General information
| Official gene symbol | CXCL5 |
|---|---|
| Entrez ID | 6374 |
| Gene full name | chemokine (C-X-C motif) ligand 5 |
| Other gene symbols | ENA-78 SCYB5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008009 | Chemokine activity | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0060326 | Cell chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000248053 | 0.7163516090 | 0.0149063830 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 3.1024003456 |
| GSE13712_SHEAR | Up | 0.0814443194 |
| GSE13712_STATIC | Up | 0.1794725319 |
| GSE19018 | Up | 0.0805061945 |
| GSE19899_A1 | Up | 5.7232561712 |
| GSE19899_A2 | Up | 8.2696419288 |
| PubMed_21979375_A1 | Up | 6.4185735563 |
| PubMed_21979375_A2 | Up | 8.4466586678 |
| GSE35957 | Down | -0.6158453727 |
| GSE36640 | Down | -0.1632601890 |
| GSE54402 | Up | 2.1255298818 |
| GSE9593 | Down | -0.7444227469 |
| GSE43922 | Up | 2.2494143018 |
| GSE24585 | Up | 0.0202481627 |
| GSE37065 | Up | 1.0165325236 |
| GSE28863_A1 | Up | 0.2141427707 |
| GSE28863_A2 | Up | 0.4539920776 |
| GSE28863_A3 | Up | 0.3276925268 |
| GSE28863_A4 | Down | -0.3125909841 |
| GSE48662 | Down | -0.4684223122 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019453 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025829 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23461802 | Gro-alpha and ENA-78 cytokine levels were significantly higher in RTH WB than Alyx RBCs during storage |
| 21084274 | Many of these induced mRNA changes are in secreted proteins, IL-6, IL-8, and IL-11 and chemokines CXCL2 and CXCL5, or genes associated with an "inflammatory" phenotype |
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