HCSGD entry for CXCL5


1. General information

Official gene symbolCXCL5
Entrez ID6374
Gene full namechemokine (C-X-C motif) ligand 5
Other gene symbolsENA-78 SCYB5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006935ChemotaxisTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008009Chemokine activityIEAmolecular_function
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0060326Cell chemotaxisTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00002480530.71635160900.01490638301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up3.1024003456
GSE13712_SHEARUp0.0814443194
GSE13712_STATICUp0.1794725319
GSE19018Up0.0805061945
GSE19899_A1Up5.7232561712
GSE19899_A2Up8.2696419288
PubMed_21979375_A1Up6.4185735563
PubMed_21979375_A2Up8.4466586678
GSE35957Down-0.6158453727
GSE36640Down-0.1632601890
GSE54402Up2.1255298818
GSE9593Down-0.7444227469
GSE43922Up2.2494143018
GSE24585Up0.0202481627
GSE37065Up1.0165325236
GSE28863_A1Up0.2141427707
GSE28863_A2Up0.4539920776
GSE28863_A3Up0.3276925268
GSE28863_A4Down-0.3125909841
GSE48662Down-0.4684223122

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019453MicroarrayFunctional MTI (Weak)17612493
hsa-miR-7-5pMIMAT0000252MIRT025829MicroarrayFunctional MTI (Weak)19073608
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23461802Gro-alpha and ENA-78 cytokine levels were significantly higher in RTH WB than Alyx RBCs during storage
21084274Many of these induced mRNA changes are in secreted proteins, IL-6, IL-8, and IL-11 and chemokines CXCL2 and CXCL5, or genes associated with an "inflammatory" phenotype
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