HCSGD entry for CCL11

1. General information

Official gene symbolCCL11
Entrez ID6356
Gene full namechemokine (C-C motif) ligand 11
Other gene symbolsSCYA11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0002544Chronic inflammatory responseIEAbiological_process
GO:0002551Mast cell chemotaxisIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007010Cytoskeleton organizationIDAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008009Chemokine activityIDAmolecular_function
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0009314Response to radiationTASbiological_process
GO:0009615Response to virusTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030838Positive regulation of actin filament polymerizationIDAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0048245Eosinophil chemotaxisIDAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0070670Response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41899733290.29352543600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3068961958
GSE13712_SHEARUp0.0303806200
GSE13712_STATICDown-0.0115259353
GSE19018Down-0.3213728529
GSE19899_A1Down-0.3593352815
GSE19899_A2Up0.2245661702
PubMed_21979375_A1Down-0.2862674085
PubMed_21979375_A2Down-0.1052292282
GSE35957Down-0.0190250271
GSE36640Down-0.1140991562
GSE54402Down-0.8060747618
GSE9593Up0.3044259261
GSE43922Up0.1476872062
GSE24585Down-0.0766635484
GSE37065Down-0.0748856896
GSE28863_A1Up0.3261573001
GSE28863_A2Up0.4445894673
GSE28863_A3Up0.5205483244
GSE28863_A4Up0.0666678301
GSE48662Up0.0938077068

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CAT-213DB05429 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019315MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22175510Chemokine CCL11/eotaxin has been identified as a factor that increases with aging
22175510Injections of CCL11 inhibit neurogenesis in young mice, an effect likely mediated by CCR3 receptors on neural stem cells
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