HCSGD entry for CCL11

1. General information

Official gene symbolCCL11
Entrez ID6356
Gene full namechemokine (C-C motif) ligand 11
Other gene symbolsSCYA11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIDAbiological_process
GO:0002544Chronic inflammatory responseIEAbiological_process
GO:0002551Mast cell chemotaxisIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006874Cellular calcium ion homeostasisTASbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007010Cytoskeleton organizationIDAbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008009Chemokine activityIDAmolecular_function
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0009314Response to radiationTASbiological_process
GO:0009615Response to virusTASbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030838Positive regulation of actin filament polymerizationIDAbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0048245Eosinophil chemotaxisIDAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060763Mammary duct terminal end bud growthIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0070670Response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41899733290.29352543600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3068961958
GSE13712_SHEARUp0.0303806200
GSE13712_STATICDown-0.0115259353
GSE19018Down-0.3213728529
GSE19899_A1Down-0.3593352815
GSE19899_A2Up0.2245661702
PubMed_21979375_A1Down-0.2862674085
PubMed_21979375_A2Down-0.1052292282
GSE35957Down-0.0190250271
GSE36640Down-0.1140991562
GSE54402Down-0.8060747618
GSE9593Up0.3044259261
GSE43922Up0.1476872062
GSE24585Down-0.0766635484
GSE37065Down-0.0748856896
GSE28863_A1Up0.3261573001
GSE28863_A2Up0.4445894673
GSE28863_A3Up0.5205483244
GSE28863_A4Up0.0666678301
GSE48662Up0.0938077068

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CAT-213DB05429 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019315MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22175510Chemokine CCL11/eotaxin has been identified as a factor that increases with aging
22175510Injections of CCL11 inhibit neurogenesis in young mice, an effect likely mediated by CCR3 receptors on neural stem cells
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