HCSGD entry for SCN1B

1. General information

Official gene symbolSCN1B
Entrez ID6324
Gene full namesodium channel, voltage-gated, type I, beta subunit
Other gene symbolsGEFSP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIDA IEAcellular_component
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0006810TransportIDAbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceISS TASbiological_process
GO:0010765Positive regulation of sodium ion transportIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0014704Intercalated discISScellular_component
GO:0015672Monovalent inorganic cation transportIDAbiological_process
GO:0017080Sodium channel regulator activityIDA IEAmolecular_function
GO:0019227Neuronal action potential propagationISSbiological_process
GO:0019871Sodium channel inhibitor activityISSmolecular_function
GO:0021966Corticospinal neuron axon guidanceISSbiological_process
GO:0030001Metal ion transportIDAbiological_process
GO:0030315T-tubuleISScellular_component
GO:0033268Node of RanvierISScellular_component
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0040011LocomotionISSbiological_process
GO:0046684Response to pyrethroidIEAbiological_process
GO:0051049Regulation of transportIDAbiological_process
GO:0051899Membrane depolarizationIDAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationISSbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0061337Cardiac conductionISSbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086006Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIMPmolecular_function
GO:0086012Membrane depolarization during cardiac muscle cell action potentialISSbiological_process
GO:0086047Membrane depolarization during Purkinje myocyte cell action potentialIMPbiological_process
GO:0086062Voltage-gated sodium channel activity involved in Purkinje myocyte action potentialIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:2000649Regulation of sodium ion transmembrane transporter activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94710553930.08319510280.99999024730.5471261054

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0926846037
GSE13712_SHEARDown-1.0785619610
GSE13712_STATICDown-0.9781891153
GSE19018Down-0.0421598647
GSE19899_A1Down-0.1888044540
GSE19899_A2Up0.0648240253
PubMed_21979375_A1Down-0.5163299138
PubMed_21979375_A2Up0.0980892407
GSE35957Down-0.5248003167
GSE36640Down-0.0782629303
GSE54402Down-0.2157475684
GSE9593Down-0.2865131532
GSE43922Up0.0572413974
GSE24585Down-0.1525074589
GSE37065Up0.0208698605
GSE28863_A1Down-0.0583018172
GSE28863_A2Up0.0913057323
GSE28863_A3Up0.1195240762
GSE28863_A4Up0.0156678692
GSE48662Down-0.0717849840

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZonisamideDB00909 APRD00004

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016821MicroarrayFunctional MTI (Weak)18185580
hsa-miR-296-3pMIMAT0004679MIRT038411CLASHFunctional MTI (Weak)23622248
hsa-miR-210-3pMIMAT0000267MIRT047007CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.