HCSGD entry for SCN1B

1. General information

Official gene symbolSCN1B
Entrez ID6324
Gene full namesodium channel, voltage-gated, type I, beta subunit
Other gene symbolsGEFSP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIDA IEAcellular_component
GO:0005248Voltage-gated sodium channel activityIDAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0006810TransportIDAbiological_process
GO:0006812Cation transportIDAbiological_process
GO:0006814Sodium ion transportIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceISS TASbiological_process
GO:0010765Positive regulation of sodium ion transportIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0014704Intercalated discISScellular_component
GO:0015672Monovalent inorganic cation transportIDAbiological_process
GO:0017080Sodium channel regulator activityIDA IEAmolecular_function
GO:0019227Neuronal action potential propagationISSbiological_process
GO:0019871Sodium channel inhibitor activityISSmolecular_function
GO:0021966Corticospinal neuron axon guidanceISSbiological_process
GO:0030001Metal ion transportIDAbiological_process
GO:0030315T-tubuleISScellular_component
GO:0033268Node of RanvierISScellular_component
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0040011LocomotionISSbiological_process
GO:0046684Response to pyrethroidIEAbiological_process
GO:0051049Regulation of transportIDAbiological_process
GO:0051899Membrane depolarizationIDAbiological_process
GO:0055085Transmembrane transportIDAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationISSbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0061337Cardiac conductionISSbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086006Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIMPmolecular_function
GO:0086012Membrane depolarization during cardiac muscle cell action potentialISSbiological_process
GO:0086047Membrane depolarization during Purkinje myocyte cell action potentialIMPbiological_process
GO:0086062Voltage-gated sodium channel activity involved in Purkinje myocyte action potentialIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:2000649Regulation of sodium ion transmembrane transporter activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94710553930.08319510280.99999024730.5471261054

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0926846037
GSE13712_SHEARDown-1.0785619610
GSE13712_STATICDown-0.9781891153
GSE19018Down-0.0421598647
GSE19899_A1Down-0.1888044540
GSE19899_A2Up0.0648240253
PubMed_21979375_A1Down-0.5163299138
PubMed_21979375_A2Up0.0980892407
GSE35957Down-0.5248003167
GSE36640Down-0.0782629303
GSE54402Down-0.2157475684
GSE9593Down-0.2865131532
GSE43922Up0.0572413974
GSE24585Down-0.1525074589
GSE37065Up0.0208698605
GSE28863_A1Down-0.0583018172
GSE28863_A2Up0.0913057323
GSE28863_A3Up0.1195240762
GSE28863_A4Up0.0156678692
GSE48662Down-0.0717849840

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZonisamideDB00909 APRD00004

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016821MicroarrayFunctional MTI (Weak)18185580
hsa-miR-296-3pMIMAT0004679MIRT038411CLASHFunctional MTI (Weak)23622248
hsa-miR-210-3pMIMAT0000267MIRT047007CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.