HCSGD entry for RYK
1. General information
| Official gene symbol | RYK |
|---|---|
| Entrez ID | 6259 |
| Gene full name | receptor-like tyrosine kinase |
| Other gene symbols | D3S3195 JTK5 JTK5A RYK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA IEA | molecular_function |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | IDA | molecular_function |
| GO:0005109 | Frizzled binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | ISS | biological_process |
| GO:0016020 | Membrane | ISS | cellular_component |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0017147 | Wnt-protein binding | IEA | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0022038 | Corpus callosum development | IEA ISS | biological_process |
| GO:0030182 | Neuron differentiation | ISS | biological_process |
| GO:0031175 | Neuron projection development | ISS | biological_process |
| GO:0042813 | Wnt-activated receptor activity | IEA | molecular_function |
| GO:0043410 | Positive regulation of MAPK cascade | IDA | biological_process |
| GO:0048705 | Skeletal system morphogenesis | IEA | biological_process |
| GO:0048843 | Negative regulation of axon extension involved in axon guidance | IEA | biological_process |
| GO:0050919 | Negative chemotaxis | IEA | biological_process |
| GO:0071679 | Commissural neuron axon guidance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9871411838 | 0.0346358079 | 0.9999902473 | 0.3526688975 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6111652196 |
| GSE13712_SHEAR | Down | -0.0367475536 |
| GSE13712_STATIC | Down | -0.0312502644 |
| GSE19018 | Up | 0.1672105403 |
| GSE19899_A1 | Down | -0.4640025569 |
| GSE19899_A2 | Down | -0.2412975129 |
| PubMed_21979375_A1 | Down | -0.3208665190 |
| PubMed_21979375_A2 | Down | -0.4866781827 |
| GSE35957 | Down | -0.0301454169 |
| GSE36640 | Down | -0.6282790204 |
| GSE54402 | Down | -0.0642833439 |
| GSE9593 | Down | -0.0374839880 |
| GSE43922 | Down | -0.2320859959 |
| GSE24585 | Down | -0.1853627327 |
| GSE37065 | Down | -0.1196026173 |
| GSE28863_A1 | Down | -0.0506586346 |
| GSE28863_A2 | Up | 0.0520003158 |
| GSE28863_A3 | Down | -0.2522529721 |
| GSE28863_A4 | Down | -0.1518311651 |
| GSE48662 | Up | 0.0670918582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002602 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025856 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-96-5p | MIMAT0000095 | 1 | hsa-miR-96 | 19363479 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
