HCSGD entry for RYK

1. General information

Official gene symbolRYK
Entrez ID6259
Gene full namereceptor-like tyrosine kinase
Other gene symbolsD3S3195 JTK5 JTK5A RYK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityTASmolecular_function
GO:0004888Transmembrane signaling receptor activityIDAmolecular_function
GO:0005109Frizzled bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIDA TASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneNAScellular_component
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0022038Corpus callosum developmentIEA ISSbiological_process
GO:0030182Neuron differentiationISSbiological_process
GO:0031175Neuron projection developmentISSbiological_process
GO:0042813Wnt-activated receptor activityIEAmolecular_function
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0048705Skeletal system morphogenesisIEAbiological_process
GO:0048843Negative regulation of axon extension involved in axon guidanceIEAbiological_process
GO:0050919Negative chemotaxisIEAbiological_process
GO:0071679Commissural neuron axon guidanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98714118380.03463580790.99999024730.3526688975

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6111652196
GSE13712_SHEARDown-0.0367475536
GSE13712_STATICDown-0.0312502644
GSE19018Up0.1672105403
GSE19899_A1Down-0.4640025569
GSE19899_A2Down-0.2412975129
PubMed_21979375_A1Down-0.3208665190
PubMed_21979375_A2Down-0.4866781827
GSE35957Down-0.0301454169
GSE36640Down-0.6282790204
GSE54402Down-0.0642833439
GSE9593Down-0.0374839880
GSE43922Down-0.2320859959
GSE24585Down-0.1853627327
GSE37065Down-0.1196026173
GSE28863_A1Down-0.0506586346
GSE28863_A2Up0.0520003158
GSE28863_A3Down-0.2522529721
GSE28863_A4Down-0.1518311651
GSE48662Up0.0670918582

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002602Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-7-5pMIMAT0000252MIRT025856MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-96-5pMIMAT00000951hsa-miR-9619363479
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.