HCSGD entry for RPS6KA2

1. General information

Official gene symbolRPS6KA2
Entrez ID6196
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 2
Other gene symbolsHU-2 MAPKAPK1C RSK RSK3 S6K-alpha S6K-alpha2 p90-RSK3 pp90RSK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001556Oocyte maturationIEAbiological_process
GO:0002035Brain renin-angiotensin systemIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0004711Ribosomal protein S6 kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005840RibosomeIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010659Cardiac muscle cell apoptotic processIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045835Negative regulation of meiosisIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0060047Heart contractionIEAbiological_process
GO:0070613Regulation of protein processingIEAbiological_process
GO:0071322Cellular response to carbohydrate stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79253686790.00036784700.99999024730.0355179487

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7034420059
GSE13712_SHEARDown-1.6770658285
GSE13712_STATICDown-1.2933246435
GSE19018Down-0.5087378124
GSE19899_A1Down-1.5145523650
GSE19899_A2Down-2.5355268040
PubMed_21979375_A1Down-3.1046346619
PubMed_21979375_A2Down-2.4431666706
GSE35957Up0.7630806196
GSE36640Down-0.0676657507
GSE54402Down-1.6217895131
GSE9593Up0.9289846819
GSE43922Down-1.8013278348
GSE24585Up0.1040452092
GSE37065Down-0.7173102719
GSE28863_A1Up0.4561684453
GSE28863_A2Up0.5299729203
GSE28863_A3Up0.0345563841
GSE28863_A4Down-0.1725624541
GSE48662Up0.0994014849

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018582MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.