HCSGD entry for RPS6KA2

1. General information

Official gene symbolRPS6KA2
Entrez ID6196
Gene full nameribosomal protein S6 kinase, 90kDa, polypeptide 2
Other gene symbolsHU-2 MAPKAPK1C RSK RSK3 S6K-alpha S6K-alpha2 p90-RSK3 pp90RSK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001556Oocyte maturationIEAbiological_process
GO:0002035Brain renin-angiotensin systemIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA TASmolecular_function
GO:0004711Ribosomal protein S6 kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005840RibosomeIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010659Cardiac muscle cell apoptotic processIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045786Negative regulation of cell cycleIDAbiological_process
GO:0045835Negative regulation of meiosisIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0060047Heart contractionIEAbiological_process
GO:0070613Regulation of protein processingIEAbiological_process
GO:0071322Cellular response to carbohydrate stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79253686790.00036784700.99999024730.0355179487

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7034420059
GSE13712_SHEARDown-1.6770658285
GSE13712_STATICDown-1.2933246435
GSE19018Down-0.5087378124
GSE19899_A1Down-1.5145523650
GSE19899_A2Down-2.5355268040
PubMed_21979375_A1Down-3.1046346619
PubMed_21979375_A2Down-2.4431666706
GSE35957Up0.7630806196
GSE36640Down-0.0676657507
GSE54402Down-1.6217895131
GSE9593Up0.9289846819
GSE43922Down-1.8013278348
GSE24585Up0.1040452092
GSE37065Down-0.7173102719
GSE28863_A1Up0.4561684453
GSE28863_A2Up0.5299729203
GSE28863_A3Up0.0345563841
GSE28863_A4Down-0.1725624541
GSE48662Up0.0994014849

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018582MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.