HCSGD entry for BCR

1. General information

Official gene symbolBCR
Entrez ID613
Gene full namebreakpoint cluster region
Other gene symbolsALL BCR1 CML D22S11 D22S662 PHL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityTASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005096GTPase activator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0016301Kinase activityTASmolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0030675Rac GTPase activator activityIEAmolecular_function
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043314Negative regulation of neutrophil degranulationIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050766Positive regulation of phagocytosisIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01162907940.43627652820.27185575221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1857150917
GSE13712_SHEARDown-0.2133045303
GSE13712_STATICDown-0.2966380790
GSE19018Up0.4389732845
GSE19899_A1Up0.4217092366
GSE19899_A2Up1.2448184756
PubMed_21979375_A1Up1.0687199887
PubMed_21979375_A2Up2.0391311575
GSE35957Up0.0092178601
GSE36640Up0.5480661269
GSE54402Up0.6748112017
GSE9593Up0.2474691298
GSE43922Up0.0987954851
GSE24585Down-0.5895050094
GSE37065Down-0.0014590136
GSE28863_A1Down-0.5469090197
GSE28863_A2Down-0.7628828920
GSE28863_A3Up0.3456693152
GSE28863_A4Down-0.1332864850
GSE48662Up0.4026950235

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BosutinibDB06616 -
PonatinibDB08901 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037631CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047744CLASHFunctional MTI (Weak)23622248
hsa-miR-197-3pMIMAT0000227MIRT048049CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25213664BCR/ABL and miR-23a expressions were inversely related to CML, and BCR/ABL expression was regulated by miR-23a in leukemic cells
20978349Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E
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