HCSGD entry for BCR
1. General information
| Official gene symbol | BCR |
|---|---|
| Entrez ID | 613 |
| Gene full name | breakpoint cluster region |
| Other gene symbols | ALL BCR1 CML D22S11 D22S662 PHL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005096 | GTPase activator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0016301 | Kinase activity | TAS | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | TAS | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030336 | Negative regulation of cell migration | IEA | biological_process |
| GO:0030675 | Rac GTPase activator activity | IEA | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043314 | Negative regulation of neutrophil degranulation | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0048008 | Platelet-derived growth factor receptor signaling pathway | IEA | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | IEA | biological_process |
| GO:0050766 | Positive regulation of phagocytosis | IEA | biological_process |
| GO:0050885 | Neuromuscular process controlling balance | IEA | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0116290794 | 0.4362765282 | 0.2718557522 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1857150917 |
| GSE13712_SHEAR | Down | -0.2133045303 |
| GSE13712_STATIC | Down | -0.2966380790 |
| GSE19018 | Up | 0.4389732845 |
| GSE19899_A1 | Up | 0.4217092366 |
| GSE19899_A2 | Up | 1.2448184756 |
| PubMed_21979375_A1 | Up | 1.0687199887 |
| PubMed_21979375_A2 | Up | 2.0391311575 |
| GSE35957 | Up | 0.0092178601 |
| GSE36640 | Up | 0.5480661269 |
| GSE54402 | Up | 0.6748112017 |
| GSE9593 | Up | 0.2474691298 |
| GSE43922 | Up | 0.0987954851 |
| GSE24585 | Down | -0.5895050094 |
| GSE37065 | Down | -0.0014590136 |
| GSE28863_A1 | Down | -0.5469090197 |
| GSE28863_A2 | Down | -0.7628828920 |
| GSE28863_A3 | Up | 0.3456693152 |
| GSE28863_A4 | Down | -0.1332864850 |
| GSE48662 | Up | 0.4026950235 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047744 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048049 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25213664 | BCR/ABL and miR-23a expressions were inversely related to CML, and BCR/ABL expression was regulated by miR-23a in leukemic cells |
| 20978349 | Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E |
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