HCSGD entry for REST

1. General information

Official gene symbolREST
Entrez ID5978
Gene full nameRE1-silencing transcription factor
Other gene symbolsNRSF XBR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006810TransportIMPbiological_process
GO:0006812Cation transportIMPbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0015271Outward rectifier potassium channel activityIMPmolecular_function
GO:0015672Monovalent inorganic cation transportIMPbiological_process
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0030001Metal ion transportIMPbiological_process
GO:0032348Negative regulation of aldosterone biosynthetic processIMPbiological_process
GO:0034220Ion transmembrane transportIMPbiological_process
GO:0034765Regulation of ion transmembrane transportIMPbiological_process
GO:0035690Cellular response to drugIMPbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045665Negative regulation of neuron differentiationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMP NASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045955Negative regulation of calcium ion-dependent exocytosisISSbiological_process
GO:0046676Negative regulation of insulin secretionIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050768Negative regulation of neurogenesisISSbiological_process
GO:0055085Transmembrane transportIMPbiological_process
GO:0060379Cardiac muscle cell myoblast differentiationISSbiological_process
GO:0070933Histone H4 deacetylationIDAbiological_process
GO:0071257Cellular response to electrical stimulusIMPbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIDAbiological_process
GO:0071805Potassium ion transmembrane transportIMPbiological_process
GO:2000065Negative regulation of cortisol biosynthetic processIMPbiological_process
GO:2000706Negative regulation of dense core granule biogenesisISSbiological_process
GO:2000740Negative regulation of mesenchymal stem cell differentiationIMPbiological_process
GO:2000798Negative regulation of amniotic stem cell differentiationIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33349615900.85754374830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0941730954
GSE13712_SHEARUp0.2356197231
GSE13712_STATICDown-0.0071726755
GSE19018Down-0.0466271103
GSE19899_A1Up0.1859338810
GSE19899_A2Down-0.1750248231
PubMed_21979375_A1Up0.2401974051
PubMed_21979375_A2Up0.1024100855
GSE35957Up0.1768100905
GSE36640Up0.0976301114
GSE54402Up0.2798182528
GSE9593Up0.0176753474
GSE43922Down-0.0290066716
GSE24585Up0.1749745388
GSE37065Up0.0794697227
GSE28863_A1Up0.0887363908
GSE28863_A2Down-0.0179822314
GSE28863_A3Down-0.2874892029
GSE28863_A4Down-0.2002770435
GSE48662Up0.7070602824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT000026Luciferase reporter assay//Western blotFunctional MTI19118166
hsa-miR-9-5pMIMAT0000441MIRT000026Luciferase reporter assayFunctional MTI19137007
hsa-miR-21-5pMIMAT0000076MIRT000177Luciferase reporter assayFunctional MTI19242418
hsa-miR-335-5pMIMAT0000765MIRT018727MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-9-5pMIMAT0000441NAhsa-miR-9{Western blot}{overexpression by miRNA precursor transfection}19118166
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.