HCSGD entry for REST

1. General information

Official gene symbolREST
Entrez ID5978
Gene full nameRE1-silencing transcription factor
Other gene symbolsNRSF XBR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006810TransportIMPbiological_process
GO:0006812Cation transportIMPbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0015271Outward rectifier potassium channel activityIMPmolecular_function
GO:0015672Monovalent inorganic cation transportIMPbiological_process
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0030001Metal ion transportIMPbiological_process
GO:0032348Negative regulation of aldosterone biosynthetic processIMPbiological_process
GO:0034220Ion transmembrane transportIMPbiological_process
GO:0034765Regulation of ion transmembrane transportIMPbiological_process
GO:0035690Cellular response to drugIMPbiological_process
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045665Negative regulation of neuron differentiationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMP NASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045955Negative regulation of calcium ion-dependent exocytosisISSbiological_process
GO:0046676Negative regulation of insulin secretionIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050768Negative regulation of neurogenesisISSbiological_process
GO:0055085Transmembrane transportIMPbiological_process
GO:0060379Cardiac muscle cell myoblast differentiationISSbiological_process
GO:0070933Histone H4 deacetylationIDAbiological_process
GO:0071257Cellular response to electrical stimulusIMPbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIDAbiological_process
GO:0071805Potassium ion transmembrane transportIMPbiological_process
GO:2000065Negative regulation of cortisol biosynthetic processIMPbiological_process
GO:2000706Negative regulation of dense core granule biogenesisISSbiological_process
GO:2000740Negative regulation of mesenchymal stem cell differentiationIMPbiological_process
GO:2000798Negative regulation of amniotic stem cell differentiationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33349615900.85754374830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0941730954
GSE13712_SHEARUp0.2356197231
GSE13712_STATICDown-0.0071726755
GSE19018Down-0.0466271103
GSE19899_A1Up0.1859338810
GSE19899_A2Down-0.1750248231
PubMed_21979375_A1Up0.2401974051
PubMed_21979375_A2Up0.1024100855
GSE35957Up0.1768100905
GSE36640Up0.0976301114
GSE54402Up0.2798182528
GSE9593Up0.0176753474
GSE43922Down-0.0290066716
GSE24585Up0.1749745388
GSE37065Up0.0794697227
GSE28863_A1Up0.0887363908
GSE28863_A2Down-0.0179822314
GSE28863_A3Down-0.2874892029
GSE28863_A4Down-0.2002770435
GSE48662Up0.7070602824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT000026Luciferase reporter assay//Western blotFunctional MTI19118166
hsa-miR-9-5pMIMAT0000441MIRT000026Luciferase reporter assayFunctional MTI19137007
hsa-miR-21-5pMIMAT0000076MIRT000177Luciferase reporter assayFunctional MTI19242418
hsa-miR-335-5pMIMAT0000765MIRT018727MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-9-5pMIMAT0000441NAhsa-miR-9{Western blot}{overexpression by miRNA precursor transfection}19118166
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.