HCSGD entry for PTPRO

1. General information

Official gene symbolPTPRO
Entrez ID5800
Gene full nameprotein tyrosine phosphatase, receptor type, O
Other gene symbolsGLEPP1 NPHS6 PTP-OC PTP-U2 PTPROT PTPU2 R-PTP-O
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisISSbiological_process
GO:0002548Monocyte chemotaxisIMPbiological_process
GO:0003093Regulation of glomerular filtrationISSbiological_process
GO:0003105Negative regulation of glomerular filtrationISSbiological_process
GO:0004725Protein tyrosine phosphatase activityIDA IEA IMP TASmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneISScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006470Protein dephosphorylationISS TASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0010812Negative regulation of cell-substrate adhesionISSbiological_process
GO:0010977Negative regulation of neuron projection developmentISSbiological_process
GO:0016021Integral component of membraneTAScellular_component
GO:0016324Apical plasma membraneISScellular_component
GO:0016328Lateral plasma membraneISScellular_component
GO:0016791Phosphatase activityISSmolecular_function
GO:0017147Wnt-protein bindingISSmolecular_function
GO:0030027LamellipodiumISScellular_component
GO:0030032Lamellipodium assemblyISSbiological_process
GO:0030424AxonISScellular_component
GO:0030426Growth coneISScellular_component
GO:0032835Glomerulus developmentIMPbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIMPbiological_process
GO:0036060Slit diaphragm assemblyISS NASbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043005Neuron projectionISScellular_component
GO:0043197Dendritic spineISScellular_component
GO:0072112Glomerular visceral epithelial cell differentiationISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayISSbiological_process
GO:0090260Negative regulation of retinal ganglion cell axon guidanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05918167240.96251450930.52732593091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4479471513
GSE13712_SHEARDown-0.1739157797
GSE13712_STATICDown-0.2167837644
GSE19018Up0.3000795597
GSE19899_A1Up0.5411205612
GSE19899_A2Up0.7032396836
PubMed_21979375_A1Down-0.1021039548
PubMed_21979375_A2Up0.8169305724
GSE35957Up0.3533902957
GSE36640Up0.2759601106
GSE54402Down-0.0244709957
GSE9593Up0.2494982241
GSE43922Up0.0124774908
GSE24585Up0.3880446457
GSE37065Down-0.0269400934
GSE28863_A1Down-0.1169675491
GSE28863_A2Down-0.0440940331
GSE28863_A3Up0.1491868982
GSE28863_A4Up0.0354459661
GSE48662Down-0.0461456580

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT000977Luciferase reporter assay//Western blotFunctional MTI18644370
hsa-miR-26b-5pMIMAT0000083MIRT029550MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.