HCSGD entry for PTPRO

1. General information

Official gene symbolPTPRO
Entrez ID5800
Gene full nameprotein tyrosine phosphatase, receptor type, O
Other gene symbolsGLEPP1 NPHS6 PTP-OC PTP-U2 PTPROT PTPU2 R-PTP-O
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisISSbiological_process
GO:0002548Monocyte chemotaxisIMPbiological_process
GO:0003093Regulation of glomerular filtrationISSbiological_process
GO:0003105Negative regulation of glomerular filtrationISSbiological_process
GO:0004725Protein tyrosine phosphatase activityIDA IEA IMP TASmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneISScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006470Protein dephosphorylationISS TASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0010812Negative regulation of cell-substrate adhesionISSbiological_process
GO:0010977Negative regulation of neuron projection developmentISSbiological_process
GO:0016021Integral component of membraneTAScellular_component
GO:0016324Apical plasma membraneISScellular_component
GO:0016328Lateral plasma membraneISScellular_component
GO:0016791Phosphatase activityISSmolecular_function
GO:0017147Wnt-protein bindingISSmolecular_function
GO:0030027LamellipodiumISScellular_component
GO:0030032Lamellipodium assemblyISSbiological_process
GO:0030424AxonISScellular_component
GO:0030426Growth coneISScellular_component
GO:0032835Glomerulus developmentIMPbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIMPbiological_process
GO:0036060Slit diaphragm assemblyISS NASbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043005Neuron projectionISScellular_component
GO:0043197Dendritic spineISScellular_component
GO:0072112Glomerular visceral epithelial cell differentiationISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayISSbiological_process
GO:0090260Negative regulation of retinal ganglion cell axon guidanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05918167240.96251450930.52732593091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4479471513
GSE13712_SHEARDown-0.1739157797
GSE13712_STATICDown-0.2167837644
GSE19018Up0.3000795597
GSE19899_A1Up0.5411205612
GSE19899_A2Up0.7032396836
PubMed_21979375_A1Down-0.1021039548
PubMed_21979375_A2Up0.8169305724
GSE35957Up0.3533902957
GSE36640Up0.2759601106
GSE54402Down-0.0244709957
GSE9593Up0.2494982241
GSE43922Up0.0124774908
GSE24585Up0.3880446457
GSE37065Down-0.0269400934
GSE28863_A1Down-0.1169675491
GSE28863_A2Down-0.0440940331
GSE28863_A3Up0.1491868982
GSE28863_A4Up0.0354459661
GSE48662Down-0.0461456580

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-5pMIMAT0000070MIRT000977Luciferase reporter assay//Western blotFunctional MTI18644370
hsa-miR-26b-5pMIMAT0000083MIRT029550MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.