HCSGD entry for BAK1

1. General information

Official gene symbolBAK1
Entrez ID578
Gene full nameBCL2-antagonist/killer 1
Other gene symbolsBAK BAK-LIKE BCL2L7 CDN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001782B cell homeostasisIEAbiological_process
GO:0001783B cell apoptotic processIEAbiological_process
GO:0001836Release of cytochrome c from mitochondriaIDA IGIbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002262Myeloid cell homeostasisIEAbiological_process
GO:0002352B cell negative selectionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneIBA TAScellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008053Mitochondrial fusionIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIBAbiological_process
GO:0008635Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome cIEAbiological_process
GO:0009620Response to fungusIEAbiological_process
GO:0010046Response to mycotoxinIEAbiological_process
GO:0010225Response to UV-CIEAbiological_process
GO:0010248Establishment or maintenance of transmembrane electrochemical gradientIDAbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0010524Positive regulation of calcium ion transport into cytosolIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031100Organ regenerationIEAbiological_process
GO:0031307Integral component of mitochondrial outer membraneISScellular_component
GO:0032469Endoplasmic reticulum calcium ion homeostasisTASbiological_process
GO:0032471Negative regulation of endoplasmic reticulum calcium ion concentrationIEAbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0034644Cellular response to UVIMP ISSbiological_process
GO:0035108Limb morphogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIBAmolecular_function
GO:0043065Positive regulation of apoptotic processIEA IMPbiological_process
GO:0043496Regulation of protein homodimerization activityIDAbiological_process
GO:0043497Regulation of protein heterodimerization activityIDAbiological_process
GO:0044346Fibroblast apoptotic processIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045862Positive regulation of proteolysisIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046902Regulation of mitochondrial membrane permeabilityIDAbiological_process
GO:0046930Pore complexIDAcellular_component
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048597Post-embryonic camera-type eye morphogenesisIEAbiological_process
GO:0051087Chaperone bindingIEAmolecular_function
GO:0051400BH domain bindingIEAmolecular_function
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0051881Regulation of mitochondrial membrane potentialIDAbiological_process
GO:0060068Vagina developmentIEAbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEAbiological_process
GO:0070242Thymocyte apoptotic processIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0090200Positive regulation of release of cytochrome c from mitochondriaIEAbiological_process
GO:0097190Apoptotic signaling pathwayIMPbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIBAbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:0097202Activation of cysteine-type endopeptidase activityIDAbiological_process
GO:1900103Positive regulation of endoplasmic reticulum unfolded protein responseIMPbiological_process
GO:1901030Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayTASbiological_process
GO:1902262Apoptotic process involved in patterning of blood vesselsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04971443710.24931461190.48894641520.9590832554

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0544235128
GSE13712_SHEARUp0.7288760104
GSE13712_STATICUp0.1819982507
GSE19018Down-0.6606836368
GSE19899_A1Up0.2989101582
GSE19899_A2Up0.9793672568
PubMed_21979375_A1Up1.0624641377
PubMed_21979375_A2Up1.0234752342
GSE35957Down-0.3058176720
GSE36640Up0.3010354185
GSE54402Up0.4998685323
GSE9593Down-0.1853593499
GSE43922Up0.8303723163
GSE24585Down-0.5006030956
GSE37065Down-0.3391024314
GSE28863_A1Down-0.2753492618
GSE28863_A2Down-0.0535170523
GSE28863_A3Down-0.3800973241
GSE28863_A4Down-0.2580936760
GSE48662Up0.1580082890

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT002394Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI18056640
hsa-miR-125b-5pMIMAT0000423MIRT002394Luciferase reporter assayFunctional MTI23497288
hsa-miR-125a-5pMIMAT0000443MIRT005350Flow//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20616003
hsa-miR-375MIMAT0000728MIRT019714MicroarrayFunctional MTI (Weak)20215506
hsa-miR-92a-3pMIMAT0000092MIRT048976CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-125b-5pMIMAT00004231hsa-miR-125b{Western blot}{Western blot}{overexpression by miRNA mimics transfection}{underexpression by anti-miRNA oligonucleotides}18056640
hsa-miR-125b-5pMIMAT0000423NAhsa-miR-125b21935352
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.