HCSGD entry for BAK1
1. General information
Official gene symbol | BAK1 |
---|---|
Entrez ID | 578 |
Gene full name | BCL2-antagonist/killer 1 |
Other gene symbols | BAK BAK-LIKE BCL2L7 CDN1 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001782 | B cell homeostasis | IEA | biological_process |
GO:0001783 | B cell apoptotic process | IEA | biological_process |
GO:0001836 | Release of cytochrome c from mitochondria | IDA IGI | biological_process |
GO:0001974 | Blood vessel remodeling | IEA | biological_process |
GO:0002262 | Myeloid cell homeostasis | IEA | biological_process |
GO:0002352 | B cell negative selection | IEA | biological_process |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005739 | Mitochondrion | IDA | cellular_component |
GO:0005741 | Mitochondrial outer membrane | IBA TAS | cellular_component |
GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
GO:0005829 | Cytosol | IEA | cellular_component |
GO:0006915 | Apoptotic process | TAS | biological_process |
GO:0007420 | Brain development | IEA | biological_process |
GO:0007568 | Aging | IEA | biological_process |
GO:0008053 | Mitochondrial fusion | IEA | biological_process |
GO:0008283 | Cell proliferation | IEA | biological_process |
GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IBA | biological_process |
GO:0008635 | Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c | IEA | biological_process |
GO:0009620 | Response to fungus | IEA | biological_process |
GO:0010046 | Response to mycotoxin | IEA | biological_process |
GO:0010225 | Response to UV-C | IEA | biological_process |
GO:0010248 | Establishment or maintenance of transmembrane electrochemical gradient | IDA | biological_process |
GO:0010332 | Response to gamma radiation | IEA | biological_process |
GO:0010524 | Positive regulation of calcium ion transport into cytosol | IEA | biological_process |
GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
GO:0031018 | Endocrine pancreas development | IEA | biological_process |
GO:0031072 | Heat shock protein binding | IEA | molecular_function |
GO:0031100 | Organ regeneration | IEA | biological_process |
GO:0031307 | Integral component of mitochondrial outer membrane | ISS | cellular_component |
GO:0032469 | Endoplasmic reticulum calcium ion homeostasis | TAS | biological_process |
GO:0032471 | Negative regulation of endoplasmic reticulum calcium ion concentration | IEA | biological_process |
GO:0033137 | Negative regulation of peptidyl-serine phosphorylation | IEA | biological_process |
GO:0034644 | Cellular response to UV | IMP ISS | biological_process |
GO:0035108 | Limb morphogenesis | IEA | biological_process |
GO:0042493 | Response to drug | IEA | biological_process |
GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
GO:0042802 | Identical protein binding | IPI | molecular_function |
GO:0042803 | Protein homodimerization activity | IBA | molecular_function |
GO:0043065 | Positive regulation of apoptotic process | IEA IMP | biological_process |
GO:0043496 | Regulation of protein homodimerization activity | IDA | biological_process |
GO:0043497 | Regulation of protein heterodimerization activity | IDA | biological_process |
GO:0044346 | Fibroblast apoptotic process | IEA | biological_process |
GO:0045471 | Response to ethanol | IEA | biological_process |
GO:0045862 | Positive regulation of proteolysis | IDA | biological_process |
GO:0046872 | Metal ion binding | IEA | molecular_function |
GO:0046902 | Regulation of mitochondrial membrane permeability | IDA | biological_process |
GO:0046930 | Pore complex | IDA | cellular_component |
GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
GO:0048597 | Post-embryonic camera-type eye morphogenesis | IEA | biological_process |
GO:0051087 | Chaperone binding | IEA | molecular_function |
GO:0051400 | BH domain binding | IEA | molecular_function |
GO:0051726 | Regulation of cell cycle | IEA | biological_process |
GO:0051881 | Regulation of mitochondrial membrane potential | IDA | biological_process |
GO:0060068 | Vagina development | IEA | biological_process |
GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA | biological_process |
GO:0070242 | Thymocyte apoptotic process | IEA | biological_process |
GO:0071260 | Cellular response to mechanical stimulus | IEP | biological_process |
GO:0090200 | Positive regulation of release of cytochrome c from mitochondria | IEA | biological_process |
GO:0097190 | Apoptotic signaling pathway | IMP | biological_process |
GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IBA | biological_process |
GO:0097193 | Intrinsic apoptotic signaling pathway | TAS | biological_process |
GO:0097202 | Activation of cysteine-type endopeptidase activity | IDA | biological_process |
GO:1900103 | Positive regulation of endoplasmic reticulum unfolded protein response | IMP | biological_process |
GO:1901030 | Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | TAS | biological_process |
GO:1902262 | Apoptotic process involved in patterning of blood vessels | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0497144371 | 0.2493146119 | 0.4889464152 | 0.9590832554 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0544235128 |
GSE13712_SHEAR | Up | 0.7288760104 |
GSE13712_STATIC | Up | 0.1819982507 |
GSE19018 | Down | -0.6606836368 |
GSE19899_A1 | Up | 0.2989101582 |
GSE19899_A2 | Up | 0.9793672568 |
PubMed_21979375_A1 | Up | 1.0624641377 |
PubMed_21979375_A2 | Up | 1.0234752342 |
GSE35957 | Down | -0.3058176720 |
GSE36640 | Up | 0.3010354185 |
GSE54402 | Up | 0.4998685323 |
GSE9593 | Down | -0.1853593499 |
GSE43922 | Up | 0.8303723163 |
GSE24585 | Down | -0.5006030956 |
GSE37065 | Down | -0.3391024314 |
GSE28863_A1 | Down | -0.2753492618 |
GSE28863_A2 | Down | -0.0535170523 |
GSE28863_A3 | Down | -0.3800973241 |
GSE28863_A4 | Down | -0.2580936760 |
GSE48662 | Up | 0.1580082890 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-125b-5p | MIMAT0000423 | MIRT002394 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18056640 |
hsa-miR-125b-5p | MIMAT0000423 | MIRT002394 | Luciferase reporter assay | Functional MTI | 23497288 |
hsa-miR-125a-5p | MIMAT0000443 | MIRT005350 | Flow//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20616003 |
hsa-miR-375 | MIMAT0000728 | MIRT019714 | Microarray | Functional MTI (Weak) | 20215506 |
hsa-miR-92a-3p | MIMAT0000092 | MIRT048976 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
---|---|---|---|---|---|---|---|
hsa-miR-125b-5p | MIMAT0000423 | 1 | hsa-miR-125b | {Western blot}{Western blot} | {overexpression by miRNA mimics transfection}{underexpression by anti-miRNA oligonucleotides} | 18056640 | |
hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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