HCSGD entry for PTPN2

1. General information

Official gene symbolPTPN2
Entrez ID5771
Gene full nameprotein tyrosine phosphatase, non-receptor type 2
Other gene symbolsPTN2 PTPT TC-PTP TCELLPTP TCPTP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004725Protein tyrosine phosphatase activityIDA IEA IMPmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0008152Metabolic processIDAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008286Insulin receptor signaling pathwayIEA ISSbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIEA ISSbiological_process
GO:0010888Negative regulation of lipid storageIEA ISSbiological_process
GO:0016311DephosphorylationIDAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019905Syntaxin bindingIPImolecular_function
GO:0030183B cell differentiationIEA ISSbiological_process
GO:0030217T cell differentiationIEA ISSbiological_process
GO:0030218Erythrocyte differentiationIEA ISSbiological_process
GO:0030971Receptor tyrosine kinase bindingIPImolecular_function
GO:0035335Peptidyl-tyrosine dephosphorylationIDA IMPbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIMPbiological_process
GO:0042512Negative regulation of tyrosine phosphorylation of Stat1 proteinIDA IMPbiological_process
GO:0042518Negative regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0042524Negative regulation of tyrosine phosphorylation of Stat5 proteinIEA ISSbiological_process
GO:0042527Negative regulation of tyrosine phosphorylation of Stat6 proteinIEA IMPbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0045650Negative regulation of macrophage differentiationIEA ISSbiological_process
GO:0045722Positive regulation of gluconeogenesisIEA ISSbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIEA ISSbiological_process
GO:0050728Negative regulation of inflammatory responseIEA ISSbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIEA ISSbiological_process
GO:0050922Negative regulation of chemotaxisIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060334Regulation of interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060336Negative regulation of interferon-gamma-mediated signaling pathwayIEA ISSbiological_process
GO:0060339Negative regulation of type I interferon-mediated signaling pathwayIEA IMPbiological_process
GO:0070104Negative regulation of interleukin-6-mediated signaling pathwayIEA IMPbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEA ISSbiological_process
GO:1902202Regulation of hepatocyte growth factor receptor signaling pathwayIMPbiological_process
GO:1902206Negative regulation of interleukin-2-mediated signaling pathwayIEA IMPbiological_process
GO:1902212Negative regulation of prolactin signaling pathwayIEA ISSbiological_process
GO:1902215Negative regulation of interleukin-4-mediated signaling pathwayIEA IMPbiological_process
GO:1902227Negative regulation of macrophage colony-stimulating factor signaling pathwayIEA ISSbiological_process
GO:1902233Negative regulation of positive thymic T cell selectionIEA ISSbiological_process
GO:2000587Negative regulation of platelet-derived growth factor receptor-beta signaling pathwayIEA ISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84740311160.35200303940.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0074045660
GSE13712_SHEARUp0.0741031697
GSE13712_STATICUp0.1370007593
GSE19018Down-0.1105292839
GSE19899_A1Down-0.0357547226
GSE19899_A2Up0.3632746418
PubMed_21979375_A1Up0.1424370440
PubMed_21979375_A2Down-0.0538081902
GSE35957Down-0.0104106309
GSE36640Down-0.6650203042
GSE54402Up0.1124869098
GSE9593Down-0.0711744976
GSE43922Up0.0269941771
GSE24585Down-0.4109997521
GSE37065Down-0.0672971460
GSE28863_A1Up0.1633308616
GSE28863_A2Up0.0118341920
GSE28863_A3Down-0.2962330121
GSE28863_A4Down-0.0098458551
GSE48662Down-0.1428253120

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.